Results 261 to 270 of about 4,503,666 (319)

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Dopaminergic signaling regulates microglial surveillance and adolescent plasticity in the mouse frontal cortex. [PDF]

Nat Commun
Stowell R, Wang KH.
europepmc   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Salivary genetic biomarkers of lung cancer: a systematic review and meta-analysis of the diagnostic accuracy. [PDF]

Cancer Cell Int
Koopaie M, Fatahzadeh M, Kolahdooz S.
europepmc   +1 more source

A mixture model for skewed mixed-type data

Eman Mohammed S. Alamer, Michael P. B. Gallaugher, Paul D. McNicholas   +2 more
openalex   +1 more source

Exam‐level analysis of lecture capture viewing and student exam performance

FEBS Open Bio, EarlyView.
This study asks how lecture capture relates to exam performance in biology courses with three noncumulative exams. Mixed‐effects modeling separated between‐students from within‐student effects on exam %. Students who watched more recordings earned higher grades, but viewing spikes above a student's own mean, consistent with cramming, predicted small ...
Kirk Hillsley
wiley   +1 more source

Impact of hyaluronic acid filler on lip impressions: a cheiloscopic study. [PDF]

J Oral Biol Craniofac Res
de Aguiar KLF, Rodrigues VP, Diniz RS, Munoz-Lora VR, Costa JF, Gonçalves-Soares LM.   +5 more
europepmc   +1 more source

Automatic Dendrogram Slicing for Mixed-Type Data Clustering

Lucio Palazzo, Alfonso Iodice D’Enza, Domenico Vistocco, Francesco Palumbo   +3 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

A scoping review protocol for the application of intersectionality in primary care research. [PDF]

Syst Rev
Urwin S, Bullen H, Abbas S, Singh P, Gillibrand S, Chatzi G, Britteon P.   +6 more
europepmc   +1 more source