Results 51 to 60 of about 119,691 (265)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The nonlocal boundary value problem with perturbations of mixed boundary conditions for an elliptic equation with constant coefficients. II

Karpatsʹkì Matematičnì Publìkacìï, 2020
In this paper we continue to investigate the properties of the problem with nonlocal conditions, which are multipoint perturbations of mixed boundary conditions, started in the first part.
Ya.O. Baranetskij, P.I. Kalenyuk, M.I. Kopach, A.V. Solomko   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Nonlocal Mixed Systems With Neumann Boundary Conditions

Mathematical Methods in the Applied Sciences
ABSTRACTWe prove well posedness and stability in for a class of mixed hyperbolic–parabolic nonlinear and nonlocal equations in a bounded domain with no flow along the boundary. While the treatment of boundary conditions for the hyperbolic equation is standard, the extension to of classical results about parabolic equations with Neumann conditions ...
Rinaldo M. Colombo, Elena Rossi, Abraham Sylla   +2 more
openaire   +3 more sources

On ordinary differential inclusions with mixed boundary conditions

Differential and Integral Equations, 2017
11 ...
MARRAS, MONICA, IANNIZZOTTO, ANTONIO, Bonanno, Gabriele   +2 more
openaire   +5 more sources

Heat kernel asymptotics with mixed boundary conditions [PDF]

Nuclear Physics B, 1999
We calculate the coefficient $a_5$ of the heat kernel asymptotics for an operator of Laplace type with mixed boundary conditions on a general compact manifold.
Branson, Thomas P., Gilkey, Peter B., Kirsten, Klaus, Vassilevich, Dmitri V.   +3 more
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

New Sequential Fractional Differential Equations with Mixed-Type Boundary Conditions

Journal of Function Spaces, 2020
In this paper, we introduce new sequential fractional differential equations with mixed-type boundary conditions CDq+kCDq−1ut=ft,ut,CDq−1ut,t∈0,1,α1u0+β1u1+γ1Iruη=ε1,η∈0,1,α2u′0+β2u′1+γ2Iru′η=ε2, where q∈1,2 is a real number, k,r>0,αi,βi,γi,εi∈ℝ,i=1,2 ...
Haiyan Zhang, Yaohong Li, Jingbao Yang
doaj   +1 more source

Spectral discretization of the time-dependent Navier-Stokes problem with mixed boundary conditions

Advances in Nonlinear Analysis, 2022
In this work, we handle a time-dependent Navier-Stokes problem in dimension three with a mixed boundary conditions. The variational formulation is written considering three independent unknowns: vorticity, velocity, and pressure.
Abdelwahed Mohamed, Chorfi Nejmeddine
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source