Mixed connective tissue disease - Open Access .click

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Overlap syndromes and mixed connective tissue disease

Current Opinion in Rheumatology, 1990
While the etiology of connective tissue diseases remains unknown, the classification of individual cases will continue to depend on identifying certain patterns of clinical and laboratory features. As many as 25% of connective tissue disease patients present with an overlap syndrome with features of systemic lupus erythematosus, systemic sclerosis ...
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Mixed Connective Tissue Disease and Renal Disease

1989
Mixed connective tissue disease (MCTD) was described in 1972 by Sharp et al (1) as a syndrome of overlapping features of systemic lupus erythematosus (SLE), progressive systemic sclerosis (PSS), and myositis. The serum of MCTD patients characteristically contained high titers of antibody to nuclear ribonucleoprotein (RNP) (2,3).
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Mixed Connective Tissue Disease

Archives of Internal Medicine, 1976
• Three patients with mixed connective tissue disease (MCTD) had clinical features that included a high incidence of Raynaud phenomenon, arthritis, myositis, and swollen hands. The diagnostic laboratory test result was the presence of high titers of antibody to extractable nuclear antigen.
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Mixed Connective Tissue Disease