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“Mixed connective tissue disease”: a condition in search of an identity [PDF]

Clinical and Experimental Medicine, 2020
Mixed connective tissue disease was first described as a new autoimmune rheumatic disease in 1972 based on the claim of a distinct clinical picture associated with anti-RNP antibody positivity.
David A. Isenberg
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Mixed Connective Tissue Disease

2008
Mixed connective tissue disease (MCTD) is a condition characterized by the overlap of features of systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and polydermatomyositis (PM/DM) in association with high titers of antibodies against a ribonuclear protein (RNP).
MOSCA, MARTA, R. Talarico, S. Bombardieri   +2 more
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MIXED CONNECTIVE TISSUE DISEASE IN CHILDREN

Rheumatology, 1978
A diagnosis of Mixed Connective Tissue Disease (MCTD) had been made in five juveniles in the past two years. All have antibodies to the ribonucleoprotein (RNP) component of extractable fluorescence pattern. No child has had life-threatening complications, though three have required steroids to control their symptoms.
S A, Peskett, B M, Ansell, P, Fizzman, A, Howard   +3 more
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Treatment of Mixed Connective Tissue Disease

Rheumatic Disease Clinics of North America, 2005
Mixed connective tissue disease (MCTD) is believed to be incurable and seems to have a variable prognosis. Some patients have a mild self-limited disease, whereas others develop major organ involvement that requires aggressive treatment. Because no controlled clinical trials have been performed to guide therapy in MCTD, treatment strategies must rely ...
Paul, Kim, Jennifer M, Grossman
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Mixed Connective Tissue Disease

Radiologic Clinics of North America, 1988
MCTD is characterized by clinical features that overlap those of several of the classic rheumatic and connective tissue disorders. Although MCTD has been distinguished from them by the presence of antibodies to an RNP and by specific immunoregulatory T cell circuit abnormalities, its definitive placement among the classic disorders remains ...
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The hand in mixed connective tissue disease

The Journal of Hand Surgery, 1978
The mixed connective tissue disease syndrome has been described in the medical literature. The clinical and serological characteristics of the syndrome are defined in this paper. The hands of these patients differ from the hands of patients with systemic lupus, rheumatoid arthritis, or systemic sclerosis. In 10 patients there were no erosive changes on
R A, Lewis, J P, Adams, N L, Gerber, J L, Decker, D B, Parsons   +4 more
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Amyloidosis in Mixed Connective Tissue Disease

Scandinavian Journal of Rheumatology, 1989
The syndrome mixed connective tissue disease (MCTD) has certain features in common with systemic lupus erythematosus (SLE), systemic sclerosis (SS), rheumatoid arthritis (RA) and polymyositis (PM) (1). The diagnosis of MCTD requires the presence of features of at least two systemic connective tissue diseases, high serum titres of antiribonucleoprotein ...
H I, Piirainen, A T, Helve, T, Törnroth, T E, Pettersson   +3 more
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Osteoporosis in mixed connective tissue disease

Clinical Rheumatology, 2003
The existence of osteoporosis in 58 postmenopausal women with mixed connective tissue disease (MCTD) was investigated. The mean bone mineral density assessed by dual energy X-ray absorptiometry in the lumbar spine was decreased in 25.8% of the patients, reflecting osteoporosis (T score < -2.5).
E, Bodolay, P, Bettembuk, A, Balogh, Z, Szekanecz   +3 more
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Mixed connective tissue disease in childhood

Pediatrics International, 1993
AbstractSince 1981, 21 children diagnosed with mixed connective tissue disease (MCTD) have been reported in detail in the literature in Japan. Overlapping clinical features and laboratory findings of these children were analyzed according to the established criteria of the Ministry of Health and Welfare, Japan.
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Pediatric Mixed Connective Tissue Disease

Current Rheumatology Reports, 2016
Pediatric-onset mixed connective tissue disease is among the rare disease entities in pediatric rheumatology and includes features of arthritis, polymyositis/dermatomyositis, systemic lupus erythematosus, and systemic sclerosis. Accurate recognition and diagnosis of the disease is paramount to prevent long-term morbidity.
Roberta A, Berard, Ronald M, Laxer
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