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Non-hepatitis-associated mixed cryoglobulinemia with polyclonal plasma cells disease and alcoholic cirrhosis: A rare case report [PDF]

Frontiers in Medicine, 2023
Mixed cryoglobulinemia refers to the serum presence of a variety of cryoglobulins, which are defined as immunoglobulins that precipitate at temperatures of < 37°C. The most common cause of mixed cryoglobulinemia is hepatitis C virus (HCV), while other
Jiao Luo, Cheng Liu, Qing-Jian Lv, Ting He, Xing Qiang, Yi Li, Qi-Mi Huang, Jia-Lin He   +7 more
doaj   +3 more sources

A Devastating Case of Hepatitis C-Induced Mixed Cryoglobulinemia [PDF]

Case Reports in Hepatology, 2021
Hepatitis C-induced mixed cryoglobulinemia leading to rapidly progressive gangrene, necessitating amputations, is a rare presentation. We describe a case of a 55-year-old man with untreated chronic hepatitis C virus (HCV) presenting with arthralgia and ...
Sameeha Khalid, Dhuha Alhankawi, Kamalmeet Kaur, Ali Ali, Anna Kazaryan, Marina Roytman   +5 more
doaj   +3 more sources

Thyroid Involvement in Hepatitis C Virus-Infected Patients with/without Mixed Cryoglobulinemia. [PDF]

Front Endocrinol (Lausanne), 2017
Thyroid involvement is a common condition that can be recorded during the natural course of different systemic rheumatic diseases, including the mixed cryoglobulinemia (MC) syndrome or cryoglobulinemic vasculitis.
Ferri C, Colaci M, Fallahi P, Ferrari SM, Antonelli A, Giuggioli D.   +5 more
europepmc   +5 more sources

Management of mixed cryoglobulinemia with rituximab: evidence and consensus-based recommendations from the Italian Study Group of Cryoglobulinemia (GISC). [PDF]

Clin Rheumatol, 2023
Cryoglobulinemic vasculitis (CV) or mixed cryoglobulinemic syndrome (MCS) is a systemic small-vessel vasculitis characterized by the proliferation of B-cell clones producing pathogenic immune complexes, called cryoglobulins.
Quartuccio L, Bortoluzzi A, Scirè CA, Marangoni A, Del Frate G, Treppo E, Castelnovo L, Saccardo F, Zani R, Candela M, Fraticelli P, Mazzaro C, Renoldi P, Scaini P, Filippini DA, Visentini M, Scarpato S, Giuggioli D, Mascia MT, Sebastiani M, Zignego AL, Lauletta G, Fiorilli M, Casato M, Ferri C, Pietrogrande M, Pioltelli PE, De Vita S, Monti G, Galli M.   +29 more
europepmc   +2 more sources

Solving the mystery of HBV-related mixed cryoglobulinemia: potential biomarkers of disease progression. [PDF]

Rheumatology (Oxford), 2021
Objectives The biomarkers of an immunological dysregulation due to a chronic HBV infection are indeed understudied. If untreated, this condition may evolve into liver impairment co-occurring with extrahepatic involvements.
Pocino K, Napodano C, Gragnani L, Ciasca G, Colantuono S, Marri S, Vantaggio L, Gulli F, Lorini S, Barini A, Stefanile A, Miele L, Casato M, Zignego AL, Rapaccini GL, Marino M, Visentini M, Basile U.   +17 more
europepmc   +2 more sources

Obinutuzumab Rescue in Rituximab Resistant Mixed Cryoglobulinemia. [PDF]

Kidney Int Rep, 2021
Kidney International Reports (2021) 6, 865–866 eradication. While initially responsive to rituximab, the patient became refractory to it, and subsequently failed cyclophosphamide, bortezomib and bendamustine.
Genest DS, Pelletier K, Dallaire G, Faucher G, Troyanov S.   +4 more
europepmc   +2 more sources

Mixed cryoglobulinemia [PDF]

Orphanet Journal of Rare Diseases, 2008
Mixed cryoglobulinemia (MC), type II and type III, refers to the presence of circulating cryoprecipitable immune complexes in the serum and manifests clinically by a classical triad of purpura, weakness and arthralgias.
Ferri Clodoveo
doaj   +4 more sources

Membranoproliferative Glomerulonephritis and Mixed Cryoglobulinemia as a Form of Presentation of Visceral Leishmaniasis. [PDF]

Am J Case Rep, 2020
Patient: Male, 69-year-old Final Diagnosis: Leishmaniasis Symptoms: Acute renal failure • purpuric skin lesions Medication: — Clinical Procedure: Bone marrow biopsy • renal biopsy • ultrasonography Specialty: Nephrology Objective: Rare co-existance of ...
Padrón Romero M, Acevedo Ribó MM, Ahijado Hormigos FJ, Díaz Crespo F, Cueto Bravo L, Herraiz Corredor C, Fernández Rojo MÁ, Díaz-Tejeiro Izquierdo R.   +7 more
europepmc   +2 more sources

Reversion of anergy signatures in clonal CD21low B cells of mixed cryoglobulinemia after clearance of HCV viremia. [PDF]

Blood, 2017
Hepatitis C virus (HCV) causes mixed cryoglobulinemia (MC) by driving clonal expansion of IgM+CD27+ B cells. These cells display both the features of anergy induced by continual engagement of the B cell receptor (BCR), such as high expression of ...
Casato, Milvia, Colantuono, Stefania, DEL PADRE, Martina, Fiorilli, Massimo, Marrapodi, Ramona, Mitrevski, Milica, Todi, Laura, Visentini, Marcella   +7 more
core   +2 more sources

Type II mixed cryoglobulinemia following influenza and pneumococcal vaccine administration. [PDF]

JAAD Case Rep, 2019
HCV: hepatitis C virus INTRODUCTION Influenza virus vaccineeinduced cryoglobulinemia has been reported in only 1 patient, whereas pneumococcal-induced cryoglobulinemia has never been described.
Eid S, Callen JP.
europepmc   +2 more sources