Results 41 to 50 of about 132,146 (266)

Control of Continuous Mixed‐Solution Mixed‐Product Removal Crystallization Processes [PDF]

Chemical Engineering & Technology, 2017
AbstractContinuous mixed‐solution mixed‐product removal (MSMPR) crystallization is considered. This process has been studied well, however, different aspects, in particular, process modeling, monitoring, and control remain challenging. An innovative approach for online measurement of the crystal size distribution is presented.
Geyyer, R., Duerr, R., Temmel, E., Li, T., Lorenz, H., Palis, S., Seidel-Morgenstern, A., Kienle, A. ; https://orcid.org/0000-0002-9011-0451   +7 more
openaire   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Understanding the History of Two Complex Ice Crystal Habits Deduced From a Holographic Imager

Geophysical Research Letters, 2023
The sizes and shapes of ice crystals influence the radiative properties of clouds, as well as precipitation initiation and aerosol scavenging. However, ice crystal growth mechanisms remain only partially characterized.
J. T. Pasquier, J. Henneberger, A. Korolev, F. Ramelli, J. Wieder, A. Lauber, G. Li, R. O. David, T. Carlsen, R. Gierens, M. Maturilli, U. Lohmann   +11 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Investigation of band gap width in mixed ZnSxSe1–x crystals

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2018
Scintillators based on ZnSxSe1–x are promising materials for X-ray and γ-ray detection. For optoelectronic devices, it is better to use semiconductor compounds with a direct-zone energy structure with its spectral range lying in the fundamental ...
O. G. Trubaieva, M. A. Chaika
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Mixed Anthrone—Anthraquinone Crystals [PDF]

Nature, 1965
A THREE-DIMENSIONAL refinement of anthrone, C14H10O (recorded m.p. 154° C) by Srivastava1 has shown that it is isostructural with anthraquinone, C14H10O2 (recorded m.p. 286° C) (refs. 2 and 3). The unit-cell dimensions and other crystallographic data are: C14H10O, m.w.
openaire   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Partition between supercooled liquid droplets and ice crystals in mixed-phase clouds based on airborne in situ observations [PDF]

Atmospheric Measurement Techniques
The onset of ice nucleation in mixed-phase clouds determines the lifetime and microphysical properties of ice clouds. In this work, we develop a novel method that differentiates between various phases of mixed-phase clouds, such as clouds dominated by ...
F. V. Maciel, F. V. Maciel, M. Diao, C. A. Yang   +3 more
doaj   +1 more source