Results 61 to 70 of about 137,357 (265)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
THE FORMATION MECHANISM OF ASSEMBLED COMPLEXES BRIDGED BY1,3–BIS(4–PYRIDYL)PROPANE [PDF]
Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2016 Several types of crystals having different color appeared in the synthesis of assembled complex of mixed crystals with three metals. [H2(bpp)][M(NCS)4] changed to 1D chain polymer (M(NCS)2(bpp)) by releasing HNCS from the cation and anion in a reaction ...
Haruka Dote +2 more
doaj
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
IEEE Photonics Journal, 2018 Cholesteric liquid crystals exhibit the characteristics of photonic crystals with a photonic bandgap. A defect-mode cholesteric liquid crystal module was assembled in this study, and laser dye and gold nanoparticles are mixed into this module.
Yu-Sung Liu, Hui-Chi Lin, Han-Lin Xu
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Stabilization of uric acid mixed crystals by melamine. [PDF]
J Cryst Growth, 2023 Ezell M +6 more
europepmc +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Emergence of the super antenna effect in mixed crystals of ytterbium and lutetium complexes showing near-infrared luminescence. [PDF]
RSC Adv, 2022 Masuya-Suzuki A +6 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source