Results 61 to 70 of about 431,056 (348)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

New Trends in Lithium Niobate: From Bulk to Nanocrystals

Crystals, 2021
The recent Special Issue on lithium niobate (LiNbO3) is dedicated to Prof. Schirmer and his topics and contains nineteen papers, out of which seven review various aspects of intrinsic and extrinsic defects in single crystals, thin films, and powdered ...
László Kovács, Gábor Corradi
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Surface roughness during depositional growth and sublimation of ice crystals [PDF]

, 2018
Full version of an earlier discussion paper (Chou et al. 2018)Ice surface properties can modify the scattering properties of atmospheric ice crystals and therefore affect the radiative properties of mixed-phase and cirrus clouds.
C. Chou, C. Chou, D. Niedermeier, F. Stratmann, G. Ritter, H. Bieligk, J. Voigtländer, P. Herenz, S. Hartmann, T. Clauss, T. Clauss, Z. Ulanowski   +11 more
core   +4 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Investigation of band gap width in mixed ZnSxSe1–x crystals

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2018
Scintillators based on ZnSxSe1–x are promising materials for X-ray and γ-ray detection. For optoelectronic devices, it is better to use semiconductor compounds with a direct-zone energy structure with its spectral range lying in the fundamental ...
O. G. Trubaieva, M. A. Chaika
doaj   +1 more source

Understanding the History of Two Complex Ice Crystal Habits Deduced From a Holographic Imager

Geophysical Research Letters, 2023
The sizes and shapes of ice crystals influence the radiative properties of clouds, as well as precipitation initiation and aerosol scavenging. However, ice crystal growth mechanisms remain only partially characterized.
J. T. Pasquier, J. Henneberger, A. Korolev, F. Ramelli, J. Wieder, A. Lauber, G. Li, R. O. David, T. Carlsen, R. Gierens, M. Maturilli, U. Lohmann   +11 more
doaj   +1 more source

Molar volume of solid isotopic helium mixtures

, 2008
Solid isotopic helium mixtures have been studied by path-integral Monte Carlo simulations in the isothermal-isobaric ensemble. This method allowed us to study the molar volume as a function of temperature, pressure, and isotopic composition.
Carlos P Herrero, Draeger E W, Feynman R P, Gillan M J, Herrero C P, Herrero C P, Herrero C P, Klein M L, Kleinert H, Landau L D, Srivastava G P, Valle R G D   +11 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Mixed Anthrone—Anthraquinone Crystals [PDF]

Nature, 1965
A THREE-DIMENSIONAL refinement of anthrone, C14H10O (recorded m.p. 154° C) by Srivastava1 has shown that it is isostructural with anthraquinone, C14H10O2 (recorded m.p. 286° C) (refs. 2 and 3). The unit-cell dimensions and other crystallographic data are: C14H10O, m.w.
openaire   +1 more source