Results 71 to 80 of about 431,056 (348)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Optical annular resonators based on radial Bragg and photonic crystal reflectors [PDF]

, 2003
A ring resonator based on Bragg reflection is studied in detail. Closed form expressions for the field and dispersion curves for radial Bragg gratings and photonic crystals based resonators are derived and compared to FDTD simulations.
Scheuer, Jacob, Yariv, Amnon
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Partition between supercooled liquid droplets and ice crystals in mixed-phase clouds based on airborne in situ observations [PDF]

Atmospheric Measurement Techniques
The onset of ice nucleation in mixed-phase clouds determines the lifetime and microphysical properties of ice clouds. In this work, we develop a novel method that differentiates between various phases of mixed-phase clouds, such as clouds dominated by ...
F. V. Maciel, F. V. Maciel, M. Diao, C. A. Yang   +3 more
doaj   +1 more source

Alignment of nematic liquid crystals on mixed Langmuir-Blodgett mono-layers

, 1997
Mono-layers of stearic and behenic acids and mixtures of them in different proportions, deposited with the Langmuir-Blodgett technique, were used to study the alignment and the alignment dynamics in nematic liquid crystal cells. A relaxation process from
Durkam, Jérôme, Komitov, L Komitov, S.T Lagerwall, V.S.U Fazio   +5 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Some effects of ice crystals on the FSSP measurements in mixed phase clouds [PDF]

Atmospheric Chemistry and Physics, 2012
In this paper, we show that in mixed phase clouds, the presence of ice crystals may induce wrong FSSP 100 measurements interpretation especially in terms of particle size and subsequent bulk parameters.
G. Febvre, J.-F. Gayet, V. Shcherbakov, C. Gourbeyre, O. Jourdan   +4 more
doaj   +1 more source

Percolation model for structural phase transitions in Li$_{1-x}$H$_x$IO$_3$ mixed crystals

, 2004
A percolation model is proposed to explain the structural phase transitions found in Li$_{1-x}$H$_x$IO$_3$ mixed crystals as a function of the concentration parameter $x$.
A.I. Barabash, C. Svensson, E. Coquet, F.E.A. Melo, F.R. Nash, G. Albrecht, J. A. Plascak, J. Le Roy, J. Le Roy, J.-M. Crettez, J.-M. Crettez, J.E. Ricci, J.P. Misset, K.J. Avdienko, M. A. Pimenta, M. Peyrard, M.A. Pimenta, M.B. Newton, M.D. Newton, M.E.J. Newman, M.E.J. Newman, M.T. Rogers, P. H. L. Martins, P.A. Giguère, P.H.L. Martins, S.A. Hamid, S.A. Hamid, S.C. van der Marck, S.K. Kurtz, W.H. Zachariasen   +29 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Structural and electronic properties of Pb1-xCdxTe and Pb1-xMnxTe ternary alloys

, 2012
A systematic theoretical study of two PbTe-based ternary alloys, Pb1-xCdxTe and Pb1-xMnxTe, is reported. First, using ab initio methods we study the stability of the crystal structure of CdTe - PbTe solid solutions, to predict the composition for which ...
A. J. Rosenberg, B. R. Nag, C. M. Hurd, F. Herman, G. D. Mahan, J. M. Ziman, K. F. Cuff, M. Bukała, M. Szot, N. G. Dhere, P. B. Allen, P. Kacman, P. Sankowski, R. Buczko, V. Leute, V. Osinniy, W. A. Harrison   +16 more
core   +1 more source