Results 71 to 80 of about 137,357 (265)

Green synthesis and biological evaluation of novel 5-fluorouracil derivatives as potent anticancer agents

Saudi Pharmaceutical Journal, 2019
This study reports the formation of 5-FU co-crystals with four different pharmacologically safe co-formers; Urea, Thiourea, Acetanilide and Aspirin using methanol as a solvent. Two fabrication schemes were followed i.e., solid-state grinding protocol, in
Farhat Jubeen, Aisha Liaqat, Misbah Sultan, Sania Zafar Iqbal, Imran Sajid, Farooq Sher   +5 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Evidence of ice crystals at cloud top of Arctic boundary-layer mixed-phase clouds derived from airborne remote sensing [PDF]

Atmospheric Chemistry and Physics, 2009
The vertical distribution of ice crystals in Arctic boundary-layer mixed-phase (ABM) clouds was investigated by airborne remote-sensing and in situ measurements during the Arctic Study of Tropospheric Aerosol, Clouds and Radiation (ASTAR) campaign in ...
B. Mayer, A. Lampert, G. Mioche, J.-F. Gayet, E. Bierwirth, M. Wendisch, A. Ehrlich   +6 more
doaj  

Growth and characterization of potassium cobalt nickel sulfate hexahydrate crystals: A new UV light filter

Journal of Science: Advanced Materials and Devices, 2017
Samples of the empirical formula K2+Nix2+Co1−x2+SO42⋅6H2O were grown with a partial occupation of the cations Co and Ni. Mixed crystals with good optical quality were obtained by the slow evaporation growth method.
Tiago S. Pacheco, Santunu Ghosh, Michelle de Oliveira, Ananias A. Barbosa, Genivaldo J. Perpétuo, Carlos J. Franco   +5 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Optical characterization of quaternary Zn1-x-yBexMgySe mixed crystals

Moldavian Journal of the Physical Sciences, 2009
We present an optical characterization of three Bridgman-grown Zn1-x-yBexMgySe mixed crystals in the near-band-edge interband transitions using temperature-dependent photoluminescence (PL), contactless electroreflectance (CER), and photoreflectance (PR)
Dumcenco, Dumitru, Huang, Ying-Sheng, Tiong, Kwong-Kaw   +2 more
doaj  

Multicomponent mixtures for cryoprotection and ligand solubilization

Biotechnology Reports, 2015
Mixed cryoprotectants have been developed for the solubilization of ligands for crystallization of protein–ligand complexes and for crystal soaking. Low affinity lead compounds with poor solubility are problematic for structural studies.
Lidia Ciccone, Laura Vera, Livia Tepshi, Lea Rosalia, Armando Rossello, Enrico A. Stura   +5 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source