Results 161 to 170 of about 17,397,740 (295)

Implementation of non-linear mixed effects models defined by fractional differential equations. [PDF]

J Pharmacokinet Pharmacodyn, 2023
Kaikousidis C, Dokoumetzidis A.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Mixed exposures research agenda; a report by the NORA Mixed Exposures Team [PDF]

"Workers are continuously exposed to a wide variety of chemical substances, biological agents, physical agents, and other stressors encountered both in and out of the workplace.

core  

Estimating multivariate longitudinal trajectories using mixed-effects models with crossed random effects. [PDF]

Behav Res Methods
Martínez-Huertas JÁ, Ferrer E.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Forecasting Patient-Specific Abdominal Aortic Aneurysm Geometry with Mixed-Effects Models. [PDF]

Diagnostics (Basel)
Restrepo JC, Bolanos ML, Baek S, Muluk SC, Eskandari MK, Kashyap VS, Yassa E, Finol EA.   +7 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Smoothing with Mixed Model Software [PDF]

Smoothing methods that use basis functions with penalization can be formulated as fits in a mixed model framework. One of the major benefits is that software for mixed model analysis can be used for smoothing.
Matthew P. Wand, Long Ngo
core  

Scale reliant mixed effects models enhance microbiome data analysis. [PDF]

Microbiome
McGovern KC, Silverman JD.
europepmc   +1 more source

Fast inference for robust nonlinear mixed-effects models. [PDF]

J Appl Stat, 2023
Gomes JCB, Aoki R, Lachos VH, Paula GA, Russo CM.   +4 more
europepmc   +1 more source