Results 181 to 190 of about 17,397,740 (295)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Inference in Mixed Proportional Hazard Models with K Random Effects [PDF]

A general formulation of Mixed Proportional Hazard models with K random effects is provided. It enables to account for a population stratified at K different levels.
Guillaume Horny.
core  

A Step-by-Step Workflow for Performing In Silico Clinical Trials With Nonlinear Mixed Effects Models. [PDF]

CPT Pharmacometrics Syst Pharmacol
Cortés-Ríos J, Magee M, Sher A, Jusko WJ, Desikan R.   +4 more
europepmc   +1 more source

lmerSeq: an R package for analyzing transformed RNA-Seq data with linear mixed effects models. [PDF]

BMC Bioinformatics, 2022
Vestal BE, Wynn E, Moore CM.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

FLASH-MM: fast and scalable single-cell differential expression analysis using linear mixed-effects models. [PDF]

Nat Commun
Xu C, Pouyabahar D, Voisin V, Heydari H, Bader GD.   +4 more
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Superior Efficacy of Tenofovir Alafenamide Compared With Entecavir in Reducing Hepatitis B Surface Antigen: A Multicentre Propensity Score-Matched Study Using Linear Mixed-Effects Models. [PDF]

Aliment Pharmacol Ther
Kumada T, Atsukawa M, Itokawa N, Arai T, Toyoda H, Tsubota A, Watanabe T, Chuma M, Matsuura K, Hiraoka A, Tada T, Takaguchi K, Kato K, Abe H, Tani J, Ishikawa T, Ogawa C, Asano T, Oikawa T, Matsumoto Y, Akita T, Tanaka J.   +21 more
europepmc   +1 more source

Bayesian Variable Selection and Estimation in Semiparametric Simplex Mixed-Effects Models with Longitudinal Proportional Data. [PDF]

Entropy (Basel), 2022
Tang A, Duan X, Zhao Y.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source