Results 81 to 90 of about 932,515 (291)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Assessment mode and inconsistent responding on a mixed-worded scale: evidence from TIMSS 2019 across grades and countries

Frontiers in Education
Understanding factors that affect inconsistent responding in mixed-worded scales is crucial for ensuring the validity of survey score outcomes. This study investigated whether the assessment mode, defined as participating either in a digital or a paper ...
Evi Konstantinidou, Evi Konstantinidou, Michalis P. Michaelides   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Iranian Pre-university Students’ Perceptions towards the English Section of the Iranian National University Entrance Exam (INUEE): A Washback Study [PDF]

Journal of English Language Teaching and Learning, 2017
Examining the effectof high-stakes tests on learners’ perceptions has been one of the strands of washback-related research.The present study purported to investigate the washback effect of the English section of theIranian National University Entrance ...
Parviz Ajideh, Leila Mahmoudi
doaj  

Region's reputation and the price of regional products: a hedonic analysis of Portuguese quality cheese [PDF]

Resources (tangible and intangible) can be mobilized to increase region's reputation and image giving a competitive advantage to certain products with origin in that region.
José Cadima Ribeiro, José Freitas Santos   +1 more
core  

Prompting Fab Yeast Surface Display Efficiency by ER Retention and Molecular Chaperon Co-expression. [PDF]

, 2019
For antibody discovery and engineering, yeast surface display (YSD) of antigen-binding fragments (Fabs) and coupled fluorescence activated cell sorting (FACS) provide intact paratopic conformations and quantitative analysis at the monoclonal level, and ...
Ge, Xin, Iverson, Brent L, Lee, Ki Baek, Li, Junhong, Mei, Meng, Wang, Shengchen, Yi, Li, Zhang, Guimin   +7 more
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Classroom expriments on project management communication [PDF]

, 2015
This manuscript gives a brief overview of three sets of experiments in the classroom with students following a Project Management (PM) course module using a blended learning approach.
Vanhoucke, Mario, Wauters, Mathieu
core   +1 more source

RECAST: Extending the Impact of Existing Analyses

, 2010
Searches for new physics by experimental collaborations represent a significant investment in time and resources. Often these searches are sensitive to a broader class of models than they were originally designed to test.
A Heister, B Bellazzini, B Bellazzini, C Cheung, CJ Flacco, F Maltoni, G Aad, G Abbiendi, G Abbiendi, Itay Yavin, J Abdallah, J Abdallah, J Alwall, Kyle Cranmer, M Dine, ND Christensen, P Achard, P Bechtle, P Meade, P Meade, PZ Skands, R Barate, R Barbieri, R Dermisek, R Dermisek, R Dermisek, S Caron, S Chang, S Chang, S Dimopoulos, S Schael, S Schael, T Aaltonen, VM Abazov   +33 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source