Results 101 to 110 of about 969,174 (273)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A Concise Study of Some Superhypergraph classes [PDF]

Neutrosophic Sets and Systems
In graph theory, the hypergraph extends the traditional graph structure by allowing edges to connect multiple vertices, and this concept is further broadened by the superhypergraph.
Florentin Smarandache, Takaaki Fujita
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Mixed Graph Colouring as Scheduling a Partially Ordered Set of Interruptible Multi-Processor Tasks with Integer Due Dates

Algorithms
We investigate relationships between scheduling problems with the bottleneck objective functions (minimising makespan or maximal lateness) and problems of optimal colourings of the mixed graphs. The investigated scheduling problems have integer durations
Evangelina I. Mihova, Yuri N. Sotskov
doaj   +1 more source

Nonlinear and oblique boundary value problems for the Stokes equations

Electronic Journal of Qualitative Theory of Differential Equations, 2011
In this paper we consider the nonlinear boundary value problem governed by a stationary perturbed Stokes system with mixed boundary conditions (Dirichlet- maximal monotone graph), in a smooth domain.
Hamid Benseridi, Mourad Dilmi
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

A novel approach to Fuzzy mixed graph structure with application towards trade relations between countries

Complex & Intelligent Systems
Many of the phenomena around us are a combination of directed and undirected relationships between different subjects, which will be more complex despite the existence of multiple relationships between objects.
Xiaolong Shi, Yongjun Dai, Ali Asghar Talebi, Hossein Rashmanlou, Seyed Hossein Sadati   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Computation of mixed resolvability for a circular ladder and its unbounded nature.

PLoS ONE
Let Γ = Γ(V ,E) be a simple, planar, connected, and undirected graph. The article primarily concentrates on a category of planar graphs, detailing the explicit identification of each member within this graph family. Within the domain of graph theory, the
Sunny Kumar Sharma, Vijay Kumar Bhat, Muhammad Azeem, Manikonda Gayathri, Bandar Almohsen   +4 more
doaj   +1 more source