Results 81 to 90 of about 2,896,689 (257)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Mediate Dominating Graph of a Graph [PDF]
, 2011 The graphs considered here are finite and simple. Let G = (V,E) be a graph and let the vertices and edges of a graph G be called the elements of G. The undefined terminology and notations can be found in [2]
Basavanagoud, B., Sunilkumar M. Hosamani
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
ON THE SECOND LARGEST EIGENVALUE OF A MIXED GRAPH [PDF]
, 2007 Let G be a mixed graph. We discuss the relation between the second largest eigenvalue λ2(G) and the second largest degree d2(G), and present a sufficient condition for λ2(G) ≥ d2(G)
Yi Wang +5 more
core +1 more source
Discrete Dynamics in Nature and Society, 2015 According to different driving behavioral characteristics of bus drivers, a cellular automata traffic model considering the bus lane changing behavior with scheduling parameters is proposed in this paper.
Zun-dong Zhang +4 more
doaj +1 more source
Do Graph Readers Prefer the Graph Type Most Suited to a Given Task? Insights from Eye Tracking
Journal of Eye Movement Research, 2016 Research on graph comprehension suggests that point differences are easier to read in bar graphs, while trends are easier to read in line graphs. But are graph readers able to detect and use the most suited graph type for a given task?
Benjamin Strobel +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source