Results 71 to 80 of about 2,896,689 (257)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Mixed Linear Layouts of Planar Graphs
, 2017 A k-stack (respectively, k-queue) layout of a graph consists of a total order of the vertices, and a partition of the edges into k sets of non-crossing (non-nested) edges with respect to the vertex ordering.
Pupyrev, Sergey, Sergey Pupyrev
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
On Mixed Metric Dimension of Some Path Related Graphs
IEEE Access, 2020 A vertex $k\in V_{G}$ determined two elements (vertices or edges) $\ell,m \in V_{G}\cup E_{G}$ , if $d_{G}(k,\ell)\neq d_{G}(k,m)$ . A set $R_ {\text {m}}$ of vertices in a graph $G$ is a mixed metric generator for $G$ , if two distinct elements
Hassan Raza, Ying Ji, Shaojian Qu
doaj +1 more source
A Demonstration of the Grrr Graph Rewriting Programming Language [PDF]
, 2000 This paper overviews the graph rewriting programming language, Grrr. The serial graph rewriting strategy is detailed, and key elements of the user interface are described.
Rodgers, Peter +3 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
m-step inverse fuzzy mixed competition graphs
International Journal of Mathematics for IndustryThe notion of competition graphs has a wide range of applications and has been utilized in designing various ecological problems and real-world competitions.
Rahul Mondal, Ganesh Ghorai
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
γ-Inverse graph of some mixed graphs
Special MatricesLet GG be a graph. Then, the inverse graph G−1{G}^{-1} of GG is defined to be a graph that has adjacency matrix similar to the inverse of the adjacency matrix of GG, where the similarity matrix is ±1\pm 1 diagonal matrix. In this article, we introduced a
Boulahmar Wafa +2 more
doaj +1 more source
Graph-based pattern identification from architecture change logs [PDF]
, 2012 Service-based architectures have become commonplace, creating the need to address their systematic maintenance and evolution. We investigate architecture change representation, primarily focusing on the identification of change patterns that support the ...
Pooyan Jamshidi (5276344) +8 more
core +2 more sources