Results 51 to 60 of about 4,540,525 (328)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Assessment of knowledge, perceptions, and readiness of healthcare professionals towards clinical pharmacogenomics implementation in Qatar: a mixed-method study

Journal of Pharmaceutical Policy and Practice
Introduction Pharmacogenomics implementation in clinical practice is anticipated to improve our understanding of individual variations in drug response and optimise the safety and efficacy of drug therapy.
Shaikha Jabor Alnaimi, Fatima Ajaj, Ahmed Awaisu, Turfa Alhathal, Shaban Mohammed, Moza Alhail   +5 more
doaj   +1 more source

“Finding Common Ground” – Impact of a Complex Intervention on Collaboration in Augmentative and Alternative Communication Care of People without Natural Speech

Journal of Multidisciplinary Healthcare, 2022
Sarah AK Uthoff,1 Anna Zinkevich,1 Jens Boenisch,2 Stefanie K Sachse,2 Tobias Bernasconi,2 Anna L Brütt,1 Lena Ansmann1 1Department of Health Services Research, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany; 2Department of Special ...
Uthoff SAK, Zinkevich A, Boenisch J, Sachse SK, Bernasconi T, Brütt AL, Ansmann L   +6 more
doaj  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Exploring the Characteristics and Preferences for Online Support Groups: Mixed Method Study

Journal of Medical Internet Research, 2019
BackgroundOsteoarthritis (OA) is a chronic, disabling, and prevalent disorder. As there is no cure for OA, long-term self-management is paramount. Support groups (SGs) can facilitate self-management among people living with OA.
Plinsinga, Melanie Louise, Besomi, Manuela, Maclachlan, Liam, Melo, Luciano, Robbins, Sarah, Lawford, Belinda J, Teo, Pek Ling, Mills, Kathryn, Setchell, Jenny, Egerton, Thorlene, Eyles, Jillian, Hall, Leanne, Mellor, Rebecca, Hunter, David J, Hodges, Paul, Vicenzino, Bill, Bennell, Kim   +16 more
doaj   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

Improving trial recruitment processes: how qualitative methodologies can be used to address the top 10 research priorities identified within the PRioRiTy study

Trials, 2018
How can we improve recruitment to trials? In their recently published paper, Healy et al. outline the top 10 prioritised questions for trial recruitment research identified by the PRioRiTy study.
Marita Hennessy, Andrew Hunter, Patricia Healy, Sandra Galvin, Catherine Houghton   +4 more
doaj   +1 more source

Affordance in Socio-Material Networks: A Mixed Method Study of Researchers' Groups and Analog-Digital Objects

Frontiers in Psychology, 2021
In this paper, we argue that we can better understand the relationship between social interaction and materiality by linking qualitative analysis of analog and digital practices, adopting Basov's model of socio-material networks.
Simone Belli
doaj   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

Age group, location or pedagogue: factors affecting parental choice of kindergartens in Hungary [PDF]

, 2015
Hungary has experienced significant political, economic, demographic and social changes since the end of Soviet domination in the 1990s. The gradual move towards liberal-democracy has been accompanied by growing emphasis on individualism, choice and ...
Adelman C., Anderson R. H., Bakonyi A., British Education Research Association, Da Silva L., Dahlberg G., de Lemos M., Denise Hevey, Eleonora Teszenyi, Elfer P., Elfer P., Fenech M., Gray P., Harris N., Hungarian Academy of Sciences (HAS), Hungarian Ministry of Culture and Education, Isaacs B., Katz L., KovácsnéBakosi É., Ministry of Human Resources, Ministry of Human Resources, Moss P., Nagy Varga A., Nicol J., Nyitrai Á., Organisation for Economic Co-operation and Development, Paszkosz A., Qvortrup J., Robinson K., Sosinsky L. S., Villányi J., Woodhead M., Yin R. K., Zsolnai A.   +33 more
core   +1 more source