Results 71 to 80 of about 4,591,548 (284)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Seasonal changes in mixed‐species bird flocks and antipredator information
Ecology and Evolution, 2020 Animals acquire information produced by other species to reduce uncertainty and avoid predators. Mixed‐species flocks (MSFs) of birds are ubiquitous in forest ecosystems and structured, in part, around interspecific information transfer, with “nuclear ...
Demeng Jiang +3 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
On the Euler characteristics of signed Selmer groups
, 2019 Let $p$ be an odd prime number, and $E$ an elliptic curve defined over a number field with good reduction at every prime of $F$ above $p$. In this short note, we compute the Euler characteristics of the signed Selmer groups of $E$ over the cyclotomic ...
Ahmed, Suman, Lim, Meng Fai
core +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Groups of order p^3 are mixed Tate
, 2015 A natural place to study the Chow ring of the classifying space BG, for G a linear algebraic group, is Voevodsky's triangulated category of motives, inside which Morel and Voevodsky, and Totaro have defined motives M(BG) and M^c(BG), respectively.
Pădurariu, Tudor
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
SAGE Open, 2020 Despite increased diversity on campuses worldwide, research has documented a lack of intercultural interaction among university students. Culturally mixed groups have been found to be a promising means of promoting the rich, repeated contact necessary ...
Shu-Wen Lan
doaj +1 more source
Psychiatry peer review groups in Australia: a mixed-methods exploration of structure and function
BMJ Open, 2020 Objectives The purpose of this study was to examine Australian psychiatrists’ experience of participation in a small group learning format of continuing professional development, known as peer review groups (PRGs), with a particular emphasis on group ...
Louise Nash +3 more
doaj +1 more source