Results 101 to 110 of about 4,256,331 (262)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Using sequence data to identify alternative routes and risk of infection: a case-study of campylobacter in Scotland [PDF]

, 2012
<b>Background:</b> Genetic typing data are a potentially powerful resource for determining how infection is acquired. In this paper MLST typing was used to distinguish the routes and risks of infection of humans with Campylobacter jejuni from
Forbes, K J, Bessell, P. R., Reid, S W J, Norval JC Strachan, Forbes, K.J., Bessell, P.R., Innocent, Giles T, Aberdeen, Innocent, G. T., Louise Matthews, Matthews, L., Glasgow, Bessell, Paul R, Ken J Forbes, Bessell, P R, Rotariu, Ovidiu, Ovidiu Rotariu, Reid, Stuart W J, Smith-Palmer, Alison, Edinburgh, Reid, S. W. J., John M Cowden, Health Protection Scotland, Cowden, J.M., Alison Smith-Palmer, Forbes, K. J., Cowden, J. M., Matthews, L, Stuart WJ Reid, Rotariu, O., Giles T Innocent, Smith-Palmer, A., Paul R Bessell, Strachan, N. J. C., Strachan, Norval J C, Matthews, Louise, Strachan, N J C, Innocent, G T, Strachan, N.J.C., Reid, S.W.J., Forbes, Ken J, Rotariu, O, Cowden, John M, Innocent, G.T., Smith-Palmer, A, Cowden, J M, Innocent Giles T, Forbes Ken J, Bessell Paul R, Rotariu Ovidiu, Strachan Norval JC, Matthews Louise, Reid Stuart WJ, Cowden John M, Smith-Palmer Alison   +54 more
core   +2 more sources

Severe pneumonia with empyema due to multiple anaerobic infections: case report and literature review

Frontiers in Medicine
BackgroundCases of severe pneumonia complicated by empyema due to normal anaerobic flora from the oral cavity are infrequent. Diagnosing anaerobic infections through conventional microbiological test (CMT) is often challenging.Case presentationThis study
Fangyu Yu, Xiaojing Zhang, Yujiao Li, Wei Gai, Yafeng Zheng, Xudong Cai   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Immune-mediated competition in rodent malaria is most likely caused by induced changes in innate immune clearance of merozoites [PDF]

, 2014
Malarial infections are often genetically diverse, leading to competitive interactions between parasites. A quantitative understanding of the competition between strains is essential to understand a wide range of issues, including the evolution of ...
Savill Nicholas Jon, Lars Raberg, Nick Savill, Nicholas Jon Savill, Råberg Lars, Jayanthi Santhanam, Nicholas Jon Savill (513813), Santhanam, Jayanthi, Råberg, Lars, Andrew F Read, Jayanthi Santhanam (513812), Santhanam Jayanthi, Råberg, Lars,, Savill, Nicholas Jon, Andrew Read, Andrew F. Read (130517), Read, Andrew F, Lars Råberg (240621), Read Andrew F., Andrew F. Read   +19 more
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Chlamydial Pneumonia in Children Requiring Hospitalization: Effect of Mixed Infection on Clinical Outcome

, 2008
The etiology of community-acquired pneumonia (CAP) in a children¡· s hospital was studied among 209 previously healthy children treated from August 1, 2001 to July 31, 2002.
TSAI, MING-HAN;HUANG, YHU-CHERING;CHANG, LUAN-YIN;LIN, TZOU-YIEN, 蔡明翰;黃玉成;張鑾英;林奏延   +1 more
core  

Immersive mixed-reality configuration of hybrid user interfaces

, 2005
Information in hybrid user interfaces can be spread over a variety of different, but complementary, displays, with which users interact through a potentially equally varied range of interaction devices. Since the exact configuration of these displays and
A. Olwal, Feiner, S., Olwal, Alex,, Sandor, C., S. Feiner, Bell, B., Olwal, A., B. Bell, C. Sandor   +8 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Urinary ATP as an indicator of infection and inflammation of the urinary tract in patients with lower urinary tract symptoms [PDF]

, 2015
BACKGROUND: Adenosine-5'-triphosphate (ATP) is a neurotransmitter and inflammatory cytokine implicated in the pathophysiology of lower urinary tract disease. ATP additionally reflects microbial biomass thus has potential as a surrogate marker of urinary
Baio, Gianluca, Malone-Lee, James, De Iorio, Maria, Sathiananamoorthy, Sanchutha, Horsley, Harry, Wildman, Scott S.P., Rohn, Jennifer L, Gill, Kiren, Khasriya, Rajvinder, Wildman, Scott, Kupelian, Anthony S   +10 more
core   +1 more source