Results 101 to 110 of about 4,094,616 (298)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Formation and Arrest of a Surface Density Front via Strain‐Driven Frontogenesis

Geophysical Research Letters
Ocean fronts play a key role in the vertical transport of heat, energy and biogeochemical tracers, but their behavior and life cycle is not well‐understood, especially at smaller scales.
Erin Atkinson, Nicolas Grisouard
doaj   +1 more source

Dataset for PCBs and OCPs in intertidal sediment and surface-mixed layer water from Lagos lagoon, southwest coast of Nigeria. [PDF]

Data Brief, 2023
Benson NU, Unyimadu JP, Tenebe IT.
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Upper ocean mixing, surface heat fluxes, and heat content variability in the upper 150 m during Hurricane Laura (2020)

Frontiers in Marine Science
This study integrates thermistor observations, hurricane glider measurements, and model-derived temperatures to examine the oceanic processes influencing Hurricane Laura’s rapid intensification, the role of the preexisting warm mixed layer at Stone ...
Senam K. Tsei, Stephan D. Howden, Arne R. Diercks, Karthik Balaguru, Matthieu Le Hénaff, Jun A. Zhang, Jun A. Zhang, Iam-Fei Pun, Kevin M. Martin   +8 more
doaj   +1 more source

Marine phytoplankton downregulate core photosynthesis and carbon storage genes upon rapid mixed layer shallowing. [PDF]

ISME J, 2023
Diaz BP, Zelzion E, Halsey K, Gaube P, Behrenfeld M, Bidle KD.   +5 more
europepmc   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Mixed-Valence State of Europium in the Misfit Layer Compound (EuS)_1.173NbS₂

, 2016
A new misfit layer compound (EuS)1.173NbS2 was synthesized, and its structure was solved in a (3+1)D superspace using the superspace group Xm2m(α00) with X referring to a pseudo F centering. The cell parameters are as = 3.3251(9) Å, bs = 5.7432(9) Å, and
Pierre Palvadeau (2954682), Alain Lafond (1471690), Laurent Cario (1669894), Catherine Deudon (2954679), Yves Moëlo (2954688), Alain Meerschaut (2654125), Benoît Corraze (2954685)   +6 more
core   +1 more source