Results 101 to 110 of about 658,858 (308)

A Review of the Linear Sufficiency and Linear Prediction Sufficiency in the Linear Model with New Observations

, 2021
We consider the general linear model y = Xβββ + εεε, denoted as M = {y, Xβββ, V}, supplemented with the new unobservable random vector y∗, coming from y∗ = X∗βββ + εεε∗, where the covariance matrix of y∗ is known as well as the cross-covariance matrix ...
Isotalo, Jarkko, Kala, Radosław, Puntanen, S., Markiewicz, Augustyn, Jarkko Isotalo, Haslett, Stephen, Puntanen, Simo, Radosław Kala, Augustyn Markiewicz, Markiewicz, A., Kala, Radoslaw, Stephen J. Haslett, Haslett, Stephen J., Simo Puntanen   +13 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Identification of functional features underlying heat stress response in Sprague-Dawley rats using mixed linear models. [PDF]

Sci Rep, 2022
Kotlarz K, Mielczarek M, Wang Y, Dou J, Suchocki T, Szyda J.   +5 more
europepmc   +1 more source

A variance shilf model for outlier detection and estimation in linear and linear mixed models

, 2008
Includes abstract.Includes bibliographical references.Outliers are data observations that fall outside the usual conditional ranges of the response data.They are common in experimental research data, for example, due to transcription errors or faulty ...
Gumedze, Freedom Nkhululeko
core  

Designs for generalized linear models with random block effects via information matrix approximations

, 2015
The selection of optimal designs for generalized linear mixed models is complicated by the fact that the Fisher information matrix, on which most optimality criteria depend, is computationally expensive to evaluate.
Waite, Timothy W, Woods, D.C., Woods, David C, Waite, T.W.   +3 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Macro vs. Micro Methods in Non-Life Claims Reserving (an Econometric Perspective)

Risks, 2016
Traditionally, actuaries have used run-off triangles to estimate reserve (“macro” models, on aggregated data). However, it is possible to model payments related to individual claims. If those models provide similar estimations, we investigate uncertainty
Arthur Charpentier, Mathieu Pigeon
doaj   +1 more source

A calibration function from change points using linear mixed models [PDF]

, 2019
The change point problem is an interesting topic in both cross-sectional and longitudinal settings. In the cross-sectional scenario, the change point problem has been studied extensively.
Garcia Cruz, Ehidy Karime
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Default Bayesian model determination methods for generalised linear mixed models

, 2010
In this paper, we consider a default strategy for fully Bayesian model determination for GLMMs. We address the two key issues of default prior specification and computation.
Overstall, Anthony M., Overstall, Antony, Forster, Jonathan, Overstall, Antony M., Forster, Jonathan J.   +4 more
core   +1 more source