Results 81 to 90 of about 11,261,456 (259)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Fitting multilevel multivariate models with missing data in responses and covariates that may include interactions and non-linear terms [PDF]
, 2012 The paper extends existing models for multilevel multivariate data with mixed response types to handle quite general types and patterns of missing data values in a wide range of multilevel generalized linear models.
Browne, William J +8 more
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
ON THE ESTIMATION AND PREDICTION IN MIXED LINEAR MODELS
Scientia Agricola, 1998 Beginning with the classical Gauss-Markov Linear Model for mixed effects and using the technique of the Lagrange multipliers to obtain an alternative method for the estimation of linear predictors. A structural method is also discussed in order to obtain
LÓPEZ L.A., IEMMA A.F.
doaj
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
"Prediction in Multivariate Mixed Linear Models" [PDF]
The multivariate mixed linear model or multivariate components of variance model with equal replications is considered.The paper addresses the problem of predicting the sum of the regression mean and the random e ects.When the feasible best linear ...
Tatsuka Kubokawa, M. S. Srivastava
core
A calibration function from change points using linear mixed models [PDF]
, 2019 The change point problem is an interesting topic in both cross-sectional and longitudinal settings. In the cross-sectional scenario, the change point problem has been studied extensively.
Garcia Cruz, Ehidy Karime
core
Generalized linear models [PDF]
, 1972 The technique of iterative weighted linear regression can be used to obtain maximum likelihood estimates of the parameters with observations distributed according to some exponential family and systematic effects that can be made linear by a suitable ...
Nelder, J. A., Wedderburn, R. W. M.
core +1 more source
Sensory analysis of Prato cheeses by generalized linear mixed models
Revista do Instituto de Latícinios Cândido TostesSensory analysis, an area of Food Science, is used to analyze and measure characteristics of foods, being able to evaluate the acceptance of samples. Such assessments can be performed using the 9-point numerical hedonic scale, classified as an ordinal ...
Tatiane Carvalho Alvarenga +1 more
doaj +1 more source