Results 71 to 80 of about 658,858 (308)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

An efficient computing strategy for prediction in mixed linear models [PDF]

, 2004
After estimation of effects from a linear mixed model, it is often useful to form predicted values for certain factor/variate combinations. This process has been well-defined for linear models, but the introduction of random effects means that a decision
Gogel, Beverley, Gogel, B., Thompson, Robin, Welham, Sue, Gilmour, A., Cullis, Brian R., Gilmour, Arthur, Welham, S. J., Thompson, R., Cullis, B. R.   +9 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Penalized Composite Likelihood Estimation for Spatial Generalized Linear Mixed Models [PDF]

Journal of Sciences, Islamic Republic of Iran
When discussing non-Gaussian spatially correlated variables, generalized linear mixed models have enough flexibility for modeling various data types. However, the maximum likelihood methods are plagued with substantial calculations for large data sets ...
Mohsen Mohammadzadeh, Leyla Salehi
doaj   +1 more source

Case-Deletion Diagnostics for Linear Mixed Models [PDF]

Technometrics, 2014
Based on the Q-function, the conditional expectation of the logarithm of the joint-likelihood between responses and random effects, we propose a case-deletion approach to identify influential subjects and influential observations in linear mixed models.
Pan, Jianxin, Fei, Yu, Foster, Peter
openaire   +4 more sources

Genetic heterogeneity of residual variance - estimation of variance components using double hierarchical generalized linear models

, 2010
Background The sensitivity to microenvironmental changes varies among animals and may be under genetic control. It is essential to take this element into account when aiming at breeding robust farm animals.
Erling Strandberg, Rönnegård, Lars, Mulder, Herman A., Felleki Majbritt, Fikse, Freddy, Rönnegård Lars, Majbritt Felleki, Ronnegard, L., Fikse Freddy, Felleki, M., Lars Rönnegård, Freddy Fikse, Herman A Mulder, Strandberg Erling, Mulder, H.A., Strandberg, Erling, Fikse, F., Felleki, Majbritt, Mulder Herman A, Strandberg, E., Rönnegård, Lars,, Felleki, Majbritt,   +21 more
core   +1 more source

Robust Classification of Functional and Quantitative Image Data Using Functional Mixed Models [PDF]

, 2012
This paper describes how to perform classification of complex, high-dimensional functional data using the functional mixed model (FMM) framework. The FMM relates a functional response to a set of predictors through functional fixed and random effects ...
Morris, Jeffrey S., Hongxiao Zhu, Zhu, Hongxiao, Philip J. Brown, Jeffrey S. Morris, Brown, Philip J.   +5 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Model selection in linear mixed effect models

Journal of Multivariate Analysis, 2012
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Heng Peng, Ying Lu 0005
openaire   +1 more source