Results 51 to 60 of about 1,975,816 (285)

Improved testing inference in mixed linear models

, 2009
Mixed linear models are commonly used in repeated measures studies. They account for the dependence amongst observations obtained from the same experimental unit.
Barndorff-Nielsen, Bartlett, Brazzale, Brown, Cox, Crepeau, Cribari-Neto, Cysneiros, DiCiccio, Doornik, Ferrari, Ferrari, Francisco Cribari-Neto, Ihaka, Lawley, Littel, Pinheiro, Sartori, Sartori, Severini, Silvia L.P. Ferrari, Tatiane F.N. Melo, Verbeke, Zucker   +23 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Identifying genetically driven clinical phenotypes using linear mixed models

Nature Communications, 2016
Use of general linear mixed models (GLMMs) in genetic variance analysis can quantify the relative contribution of additive effects from genetic variation on a given trait.
Jonathan D. Mosley, John S. Witte, Emma K. Larkin, Lisa Bastarache, Christian M. Shaffer, Jason H. Karnes, C. Michael Stein, Elizabeth Phillips, Scott J. Hebbring, Murray H. Brilliant, John Mayer, Zhan Ye, Dan M. Roden, Joshua C. Denny   +13 more
doaj   +1 more source

The Discrete Dantzig Selector: Estimating Sparse Linear Models via Mixed Integer Linear Optimization

, 2017
We propose a novel high-dimensional linear regression estimator: the Discrete Dantzig Selector, which minimizes the number of nonzero regression coefficients subject to a budget on the maximal absolute correlation between the features and residuals ...
Mazumder, Rahul, Radchenko, Peter
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Exploring efficient linear mixed models to detect quantitative trait locus-by-environment interactions

G3: Genes, Genomes, Genetics, 2021
Genotype-by-environment (G × E) interactions are important for understanding genotype–phenotype relationships. To date, various statistical models have been proposed to account for G × E effects, especially in genomic selection (GS) studies.
Eiji Yamamoto, Hiroshi Matsunaga
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Spatial Autoregressive Modeling on Linear Mixed Models for Dependency Between Regions

Aceh International Journal of Science and Technology, 2023
This study develops a linear mixed model (LMM) that includes spatial effects between regions with a spatial autoregressive model (SAR model). Between observations (regions) on that LMM are usually assumed to be independent. However, these assumptions are
Timbang Sirait
doaj   +1 more source

Efficient estimation of moments in linear mixed models

, 2012
In the linear random effects model, when distributional assumptions such as normality of the error variables cannot be justified, moments may serve as alternatives to describe relevant distributions in neighborhoods of their means.
Stute, Winfried, Wu, Ping, Zhu, Li-Xing
core   +1 more source