Results 171 to 180 of about 6,168,058 (280)

Febrile Seizures in an App-Based Children's Fever Registry: Mixed Methods Study. [PDF]

JMIR Pediatr Parent
Martin D, Möhler R, Germann CB, Gwiasda M, Schwarz S, Jenetzky E.   +5 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Understanding the Lived Experience and Bereavement of Caregivers of People with Alzheimer's Disease: A Mixed-Methods Study Protocol. [PDF]

Healthcare (Basel)
Risquez-Salgado N, García-Bravo S, Huertas-Hoyas E, Pérez-Corrales J, Salcedo-Perez-Juana M, Donovan M, Palacios-Ceña D, Bullón-Benito E, García-Bravo C.   +8 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Positive Insights on Student Research Engagement in Academic Undergraduate General Practice: A Mixed Methods Study. [PDF]

Clin Teach
Ravichandran N, Carberry C, Clendennen N, Broughan J, McCombe G, Cullen W.   +5 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Older Adults' Experiences of Commercial Virtual Reality for Stroke Rehabilitation: A Mixed-Methods Study. [PDF]

Medicina (Kaunas)
Kim M, Thawisuk C, Uetake S, Kim HD.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Health care professionals' postpartum nutritional counselling to women; a mixed-methods approach. [PDF]

BMC Health Serv Res
Faessen JPM, Mattijssen S, van Lonkhuijzen RM, Feskens EJM, Wagemakers A, Brouwer-Brolsma EM.   +5 more
europepmc   +1 more source

The thorny issue of pluralism, 'paradigm wars' and politics in qualitative methods and mixed methods research [PDF]

, 2014
Bridger, Alexander J.
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