Results 211 to 220 of about 2,900,458 (300)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Patient Experience of Emergency Laparotomy: A Mixed Methods Study (The PEEL-2 Study). [PDF]

World J Surg
Silva LM, Mohammed SA, Strong PJ, Dietrich A, Watts T, Bisson J, Torkington J, Cornish JA.   +7 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Strengthening HIV Programs in Sub-Saharan Africa Through Implementation Research: A Mixed-Methods Systematic Review. [PDF]

AIDS Res Treat
Bwire GM, Nyondo GG, Njiro BJ, Aiko BG, Mikomangwa WP, Manguzu MA, August F, Myemba DT, Magati R, Chillo P, Mugusi F, Bakari M, Sudfeld C, Sangeda RZ, Killewo J.   +14 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Athletes' psychological strain, negative emotions, and suicidal ideation: a mixed methods study. [PDF]

BMC Psychiatry
Hu C, Huang W, Zhang W, Qin J, Zhang J.
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

I HAVE A RESEARCH IDEA, NOW WHAT? A PRACTICAL GUIDE TO RESEARCH METHOD SELECTION IN SPORT MANAGEMENT

Dynamic Relationships Management Journal (DRMJ)
Jure Andolšek
doaj   +1 more source

Differentiated instruction in Indonesian primary school physical education: a mixed-methods study. [PDF]

Front Sports Act Living
Suherman WS, Prasetyo Y, Guntur G, Rismayanthi C, Podung BJ, Firdaus K, Pramono H, Priyono B, Suherman A, Siahaan J, Fakhrurozi ZA, Ningsih AG, Amran.   +12 more
europepmc   +1 more source