Results 61 to 70 of about 2,640,675 (296)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Action Research as a Mixed Methods Design: A palliative approach in residential aged care
, 2009 This chapter contains sections titled: Introduction The Residential-Palliative Approach Competency (R-PAC) Project Reconciling mixed methods research in an action research paradigm Historical background of action research Relevance of action research to ...
Patricia M. Davidson +5 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Appraising Mixed Methods Research
, 2018 There is increasing interest in the use of mixed methods research approaches among health researchers. While mixed methods research has the potential to reveal rich data and deeper understandings of complex phenomena, it needs to be evaluated with the ...
Elizabeth J. Halcomb +1 more
core +1 more source
Barriers to and facilitators of physical activity in pediatric pulmonary hypertension
Pulmonary CirculationTherapeutic exercise has not been widely adopted in pediatric pulmonary hypertension (PH), despite adult data supporting its safety and efficacy. While physical limitations may prevent children with PH from participating in physical activity, other ...
Catherine M. Avitabile +7 more
doaj +1 more source
Digital transformation preparedness: an exploratory study [PDF]
Digital Transformation and SocietyPurpose – Digital transformation (DT) harnessing the potential of emerging technology creates opportunities and challenges for organizations worldwide.
Anil Kumar +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 2021 Traditional evaluation techniques are often not suitable for studying health interventions operating in real-world settings, particularly when interventions operate through complex causal pathways.
Chan, AWM +4 more
core +1 more source
Mixed Methods in Finance Research
International Journal of Qualitative Methods, 2018 The purpose of this study is to uncover the rationale (why) and the types of designs (what) for application of mixed method approaches in finance research using a systematic literature review approach.
N. J. Dewasiri +2 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source