Results 61 to 70 of about 60,348,366 (292)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
, 2020 In this globalized era, mixed methods research (MMR) is widely utilized in various social and cultural research fields. However, integrating the qualitative and quantitative data rather than combining findings from both approaches remains a challenge for
Liu, Honggang, Li, Zongqiang
core +1 more source
Journal of Research in Nursing, 2006 The claim that mixed methods is the third methodological movement of the twentieth century could have unexpected consequences for the future of research in the social sciences and health disciplines. Implied is a belief that the mixing of qualitative and quantitative methods will produce the ‘best of both worlds’.
openaire +2 more sources
Digital transformation preparedness: an exploratory study [PDF]
Digital Transformation and SocietyPurpose – Digital transformation (DT) harnessing the potential of emerging technology creates opportunities and challenges for organizations worldwide.
Anil Kumar +3 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Barriers to and facilitators of physical activity in pediatric pulmonary hypertension
Pulmonary CirculationTherapeutic exercise has not been widely adopted in pediatric pulmonary hypertension (PH), despite adult data supporting its safety and efficacy. While physical limitations may prevent children with PH from participating in physical activity, other ...
Catherine M. Avitabile +7 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Action Research as a Mixed Methods Design: A palliative approach in residential aged care
, 2009 This chapter contains sections titled: Introduction The Residential-Palliative Approach Competency (R-PAC) Project Reconciling mixed methods research in an action research paradigm Historical background of action research Relevance of action research to ...
Patricia M. Davidson +5 more
core +1 more source
Mixed Methods in Finance Research
International Journal of Qualitative Methods, 2018 The purpose of this study is to uncover the rationale (why) and the types of designs (what) for application of mixed method approaches in finance research using a systematic literature review approach.
N. J. Dewasiri +2 more
doaj +1 more source