Results 71 to 80 of about 2,640,675 (296)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Untangling the meanings of justice: a longitudinal mixed method study

open access: yes, 2018
This article explores the application of prospective and retrospective elements of enquiry at different time points in longitudinal mixed methods research.
Holder, Robyn L
core   +1 more source

Mixed Methods and Action Research: similar or different?

open access: yesGlottodidactica, 2011
This article attempts to analyse and compare ELT studies grounded solely in mixed methods and ELT action research studies based on a mixed methods approach in order to identify to what degree action research studies combining different methods in a ...
Danuta Wiśniewska
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

The thorny issue of pluralism, 'paradigm wars' and politics in qualitative methods and mixed methods research

open access: yes, 2014
MIXED METHODS RESEARCH is clearly a recognized area of research in psychology. With the ascendancy of that work there does need to be a sustained debate surround methods and approaches in psychology.
Bridger, Alexander   +1 more
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Mixed methods in health care research. Paradigms and philosphy [PDF]

open access: yes, 2018
When to use mixed methods is one of the most challenging issues that health care researchers currently face. The predominance of quantitative methods have not been enough to respond to many relevant questions on health care, that need a multiple approach.
Kendall, Sally
core  

Analysing mixed methods data

open access: yes, 2009
The primary focus of the chapter is on strategies for analysis in mixed methods research. Analysing mixed methods data generally assumes competence in analysing, separately, both quantitative (statistical) and qualitative (textual) data.
Bazeley, Pat (R13373), Patricia Bazeley
core   +1 more source

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