Results 91 to 100 of about 60,348,366 (292)
From mixed data sources to multimethods and integrative mixed methods
, 2023 Business and management researchers frequently draw on mixed data sources and multiple methods for their research, but they rarely fully exploit their integrative potential.
Bazeley, Pat (R13373)
core +1 more source
Education SciencesDespite growing awareness of the emotional challenges faced by engineering students and their impact on academic performance and retention, the field lacks validated tools to systematically assess affective states in theoretically grounded ways.
Gibin Mannathikulathil Raju +2 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Integrating data analyses in mixed methods research
, 2009 Although the epistemological arguments of the ‘‘paradigm wars’’ sharpened our thinking about issues related to mixed methodology, their lingering legacy has been to slow the progress of integration of methods.
Bazeley, Pat (R13373)
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The "movement" of mixed methods research and the role of educators
South African Journal of Education, 2008 The landscape of research is continually evolving, enabling researchers to study increasingly complex phenomena. Educational researchers have propelled much of this forward progress and have developed novel methodologies to provide increasingly sound and
John W. Creswell, Amanda L. Garrett
doaj
Use of Mixed Method in Marketing Research: A Content Analysis [PDF]
Interdisciplinary Description of Complex SystemsWhile the integration of qualitative and quantitative research methods has been relatively rare, it has been applied in numerous studies over the years. However, a standardized framework for combining different data collection methods remains elusive. As
Mustafa Polat, Yusuf Öcel
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source