Poloxamer-188 and d-α-Tocopheryl Polyethylene Glycol Succinate (TPGS-1000) Mixed Micelles Integrated Orodispersible Sublingual Films to Improve Oral Bioavailability of Ebastine; In Vitro and In Vivo Characterization. [PDF]
Pharmaceutics, 2021 Orodispersible sublingual films (OSFs) composed of hydrophilic polymers were loaded with poloxamer-188 and d-α-tocopheryl polyethylene glycol succinate (TPGS-1000) mixed micelles to improve the oral bioavailability of a poorly soluble drug, ebastine (EBT)
Islam N +11 more
europepmc +4 more sources
Enhanced oral bioavailability of magnolol via mixed micelles and nanosuspensions based on Soluplus®-Poloxamer 188. [PDF]
Drug Deliv, 2020 Magnolol, known to have extensive biological activities, is the major bioactive ingredient isolated from the root and stem bark of Magnolia officinalis.
Li G, Lu Y, Fan Y, Ning Q, Li W.
europepmc +4 more sources
Low- q Bicelles Are Mixed Micelles. [PDF]
J Phys Chem Lett, 2018 Bicelles are used in many membrane protein studies because they are thought to be more bilayer-like than micelles. We investigated the properties of "isotropic" bicelles by small-angle neutron scattering, small-angle X-ray scattering, fluorescence anisotropy, and molecular dynamics. All data suggest that bicelles with a q value below 1 deviate from the
Caldwell TA +8 more
europepmc +5 more sources
Targeted delivery of quercetin by biotinylated mixed micelles for non-small cell lung cancer treatment. [PDF]
Drug Deliv, 2022 Lung cancer is the leading cause of cancer death world-wide and its treatment remains a challenge in clinic, especially for non-small cell lung cancer (NSCLC). Thus, more effective therapeutic strategies are required for NSCLC treatment.
Li K +5 more
europepmc +2 more sources
pH-Sensitive Mixed Micelles Assembled from PDEAEMA-PPEGMA and PCL-PPEGMA for Doxorubicin Delivery: Experimental and DPD Simulations Study. [PDF]
Pharmaceutics, 2020 To decrease critical micelle concentration (CMC), improve stability, and keep high drug-loading capacity, three pH-sensitive mixed micelles applied for anticancer drug controlled delivery were prepared by the mixture of polymers poly (N,N ...
Yang C +10 more
europepmc +2 more sources
Liver-Targeting and pH-Sensitive Sulfated Hyaluronic Acid Mixed Micelles for Hepatoma Therapy. [PDF]
Int J Nanomedicine, 2019 Background The tumor-targeting ability and pH-sensitive properties of intelligent drug delivery systems are crucial for effective drug delivery and anti-tumor therapy.
Li ZP +8 more
europepmc +2 more sources
A Novel Gel-Forming Solution Based on PEG-DSPE/Solutol HS 15 Mixed Micelles and Gellan Gum for Ophthalmic Delivery of Curcumin. [PDF]
Molecules, 2019 Curcumin (Cur) is a naturally hydrophobic polyphenol with potential pharmacological properties. However, the poor aqueous solubility and low bioavailability of curcumin limits its ocular administration.
Sai N +13 more
europepmc +2 more sources
Phytol-mixed micelles alleviate dexamethasone-induced osteoporosis in zebrafish: Activation of the MMP3-OPN-MAPK pathway-mediating bone remodeling. [PDF]
Open Life SciLiu B, Wang P, Lv X.
europepmc +3 more sources
Thymoquinone-Loaded Soluplus®-Solutol® HS15 Mixed Micelles: Preparation, In Vitro Characterization, and Effect on the SH-SY5Y Cell Migration. [PDF]
Molecules, 2020 Bergonzi MC +4 more
europepmc +3 more sources
International Journal of Nanomedicine, 2017 The roles of ginsenoside compound K (CK) in inhibiting tumor have been widely recognized in recent years. However, low water solubility and significant P-gp efflux have restricted its application.
Youwen Zhang +6 more
openalex +3 more sources