Results 131 to 140 of about 46,059 (265)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Fracture mechanisms and failure criteria of adhesive joints and toughened epoxy adhesives
, 2010 PhDAdhesive bonded applications are used widely in industry because of significant advantages such as uniform stress distribution, and the ability to join different materials.
Xu, Botao
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
高強度GFRP積層板の層間はく離疲労き裂進展におよぼす混合モード比の影響 [PDF]
, 2004 The effect of mode mixty on fatigue crack growth behavior from delamination was investigated with UD laminates (made of unidirectional laminates) and C laminates (made of unidirectional laminates and cloth laminates) of high strength glass fiber ...
仁瓶, 寛太 +7 more
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Mode effect or question wording? Measurement error in mixed mode surveys.
[Dataset available: http://hdl.handle.net/10411/17672]
Hox, J.J.C.M. +2 more
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, 2011 This the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 John Wiley & Sons, Ltd.In this paper, the distributed state estimation problem is investigated for a class of sensor ...
Zidong Wang +5 more
core +1 more source
Fracture and Structural Integrity, 2015 In this study, experimental and numerical results of compact tension shear (CTS) specimen and a new specimen type under in-plane mixed mode (Mode-I/II) loading conditions are compared with existing inplane mixed mode fracture criteria to investigate and ...
A. O. Ayhan, O. Demir
doaj