Results 151 to 160 of about 1,992,399 (301)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Mixed-mode cooling.

open access: yes, 2006
However, the availability in the 1950s of large-scale mechanical cooling, along with other technologies such as curtain walls and fluorescent lighting, led to the more common building forms we see today in North America—typically all-glass, flush-skin buildings with large floor plates and no operable windows.Our technological capabilities allow ...
openaire   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Modeling, environmental and economic analysis of drying of orange slice in an automatic indirect mixed mode solar dryer. [PDF]

open access: yesSci Rep
Elwakeel AE   +9 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

The Australian mixed-mode observing program. [PDF]

open access: yesJ Geod, 2022
McCallum L   +9 more
europepmc   +1 more source

Mixed-Mode Fuel Minimization

open access: yes, 2011
A mixed-mode method for operating a vehicle's propulsion plant to travel at a selected average speed using the minimum amount of fuel. The method involves travelling in one mode at high speed part of the time, and in a different mode at low speed part of the time, in such a way that the average speed is the selected value.
Brown, Gerald Gerard   +4 more
openaire   +1 more source

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