Results 41 to 50 of about 580,433 (262)
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Mixed Mode Crack Propagation in Iliac Bone
Bone is a complex material that can be regarded as an anisotropic elastic composite material. The problem of crack propagation in human bone is analyzed by using a generalization of the maximum tensile stress criterion (MTS).
Baesu E. +3 more
doaj +1 more source
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Measurement equivalence in mixed mode surveys
Surveys increasingly use mixed mode data collection (e.g., combining face-to-face and web) because this controls costs and helps to maintain good response rates.
Joop J. Hox +2 more
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Reconfigurable Mixed Mode Universal Filter
This paper presents a novel mixed mode universal filter configuration capable of working in voltage and transimpedance mode. The proposed single filter configuration can be reconfigured digitally to realize all the five second order filter functions ...
Neelofer Afzal, Devesh Singh
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Measuring and testing the interview mode effect in mixed mode surveys
Many studies are showing an increased tendency to use more than one data collection mode for a particular survey. However, mixed data collection modes may influence responses given by interviewees and require researchers to verify if differences in ...
Furio Camillo, Ida D'Attoma
doaj +1 more source
Chaotic Turing-Hopf mixed mode
An alternative scenario for the onset of spatiotemporal chaos in one-dimensional extended systems arising from a phase instability of a Turing-Hopf mixed mode is presented. This mechanism leads to weak and defect turbulences. The transition between these two is either continuous or hysteretic, depending on the values of the parameters.
De Wit, Anne +2 more
openaire +3 more sources

