Results 111 to 120 of about 3,604,166 (239)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

DGA-Models of variations of mixed Hodge structures

, 2018
We define objects over Morgan's mixed Hodge diagrams which will be algebraic models of unipotent variations of mixed hodge structures over K\"ahler manifolds.
Kasuya, Hisashi
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Nonparametric Density Estimation in a Mixed Model Using Wavelets

Axioms
This paper investigates nonparametric estimations of a density function within a mixed density model. A linear wavelet density estimator and an adaptive nonlinear wavelet estimator are proposed using wavelet method and hard thresholding algorithm.
Dan Liang, Junke Kou
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Selection of High-Yielding Genotypes of Coffea canephora at Transitional Altitude: Adaptability and Stability and Impacts of Water Management

Horticulturae
Expanding Coffea canephora cultivation to transitional altitudes offers a promising strategy to sustain coffee production under climate change. This study evaluated 27 genotypes cultivated under two water management regimes (fully and minimally irrigated)
Tafarel Victor Colodetti, Wagner Nunes Rodrigues, João Felipe de Brites Senra, Marcelo Curitiba Espindula, José Francisco Teixeira do Amaral, José Domingos Cochicho Ramalho, Marcelo Antonio Tomaz   +6 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Structural Equation Modeling of Genetic and Residual Covariance Matrices for Multiple-Trait Evaluation in Beef Cattle

Animals
The continuous growth in both the number of phenotypic records and the range of traits included in beef cattle genetic evaluations poses substantial statistical and computational challenges for the estimation of genetic and residual (co)variance matrices
Marcos Jun-Iti Yokoo, Gustavo de los Campos, Vinícius Silva Junqueira, Fernando Flores Cardoso, Guilherme Jordão Magalhães Rosa, Lucia Galvão Albuquerque   +5 more
doaj   +1 more source