Results 121 to 130 of about 2,175,866 (311)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

S-estimation and a robust conditional Akaike information criterion for linear mixed models. [PDF]

We study estimation and model selection on both the fixed and the random effects in the setting of linear mixed models using outlier robust S-estimators.
Tharmaratnam, Kukatharmini, Claeskens, Gerda   +1 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Nonparametric Density Estimation in a Mixed Model Using Wavelets

Axioms
This paper investigates nonparametric estimations of a density function within a mixed density model. A linear wavelet density estimator and an adaptive nonlinear wavelet estimator are proposed using wavelet method and hard thresholding algorithm.
Dan Liang, Junke Kou
doaj   +1 more source

Heterogeneous host susceptibility enhances prevalence of mixed-genotype micro-parasite infections

, 2011
Dose response in micro-parasite infections is usually shallower than predicted by the independent action model, which assumes that each infectious unit has a probability of infection that is independent of the presence of other infectious units. Moreover,
Zwart, Mark P., Lia Hemerik, Hemerik, L., Just M. Vlak, Mark P. Zwart, Mark P Zwart, Vlak, J.M., van der Werf, Wopke, van der Werf Wopke, Hemerik, Lia, Just M Vlak, Hemerik Lia, Vlak Just M., Zwart Mark P., Zwart, M.P., Wopke van der Werf, Vlak, Just M., Werf, W., van der, van der Werf, W.   +18 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Selection of High-Yielding Genotypes of Coffea canephora at Transitional Altitude: Adaptability and Stability and Impacts of Water Management

Horticulturae
Expanding Coffea canephora cultivation to transitional altitudes offers a promising strategy to sustain coffee production under climate change. This study evaluated 27 genotypes cultivated under two water management regimes (fully and minimally irrigated)
Tafarel Victor Colodetti, Wagner Nunes Rodrigues, João Felipe de Brites Senra, Marcelo Curitiba Espindula, José Francisco Teixeira do Amaral, José Domingos Cochicho Ramalho, Marcelo Antonio Tomaz   +6 more
doaj   +1 more source

Permeation model and experimental investigation of mixed conducting membranes

, 2012
A simple oxygen permeation model was developed based on the theoretical analysis of the role of interfaces of mixed conducting membranes. The developed model equations contain three resistance constants, which can be determined by correlating oxygen ...
朱雪峰, 杨维慎, Zhu, Xuefeng, Yang, Weishen, Cong, You, Liu, Huanying   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Structural Equation Modeling of Genetic and Residual Covariance Matrices for Multiple-Trait Evaluation in Beef Cattle

Animals
The continuous growth in both the number of phenotypic records and the range of traits included in beef cattle genetic evaluations poses substantial statistical and computational challenges for the estimation of genetic and residual (co)variance matrices
Marcos Jun-Iti Yokoo, Gustavo de los Campos, Vinícius Silva Junqueira, Fernando Flores Cardoso, Guilherme Jordão Magalhães Rosa, Lucia Galvão Albuquerque   +5 more
doaj   +1 more source