Results 121 to 130 of about 1,828,929 (311)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Multivariate functional mixed model with MRI data: An application to Alzheimer's disease [PDF]

, 2023
Haotian Zou, Luo Xiao, Donglin Zeng, Sheng Luo, for the Alzheimer's Disease Neuroimaging Initiative   +4 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

“Mixed” occupancy designs: When do additional single-visit data improve the inferences from standard multi-visit models?

, 2023
Gesa von Hirschheydt, Silvia Stofer, Marc Kéry   +2 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Future Scenarios of Global Urban Expansion and Carbon Emissions with National Heterogeneity: A Mixed-Effects Model Based on Urban Nighttime Lights [PDF]

Junrui Xu, Masanobu Kii, Yasunori Okano, Chun-Chen Chou   +3 more
openalex   +1 more source

Worldwide impact of economic cycles on suicide trends over 3 decades: differences according to level of development. A mixed effect model study [PDF]

, 2012
Hilario Blasco-Fontecilla, M. Mercedes Pérez-Rodríguez, Rebeca García Nieto, Pablo Fernández‐Navarro, Hanga Galfalvy, José de León, Enrique Baca‐García   +6 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

A Novel Gibbs Maximum a Posteriori (GMAP) Approach on Bayesian Nonlinear Mixed-Effects Population Pharmacokinetics (PK) Models

, 2009
Seongho Kim, Stephen D. Hall, Lang Li
openalex   +1 more source

Analysis of  the Mixed Effects Regression Model for Clustered Count Response Data [PDF]

, 2020
Aragaw Eshetie Aguade, Muniswamy Begari
openalex   +1 more source