Results 71 to 80 of about 2,175,866 (311)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Joint Predictors of Hypertension and Type 2 Diabetes Among Adults Under Treatment in Amhara Region (North-Western Ethiopia)

Diabetes, Metabolic Syndrome and Obesity, 2021
Awoke Seyoum Tegegne Department of Statistics, Bahir Dar University, Bahir Dar, EthiopiaCorrespondence: Awoke Seyoum TegegneDepartment of Statistics, Bahir Dar University, Bahir Dar, EthiopiaTel +251918779451Email bisrategebrail@yahoo.comBackground: One ...
Tegegne AS
doaj  

Mixed Methods for Mixed Models

, 2014
This work bridges the frequentist and Bayesian approaches to mixed models by borrowing the best features from both camps: point estimation procedures are combined with priors to obtain accurate, fast inference while posterior simulation techniques are developed that approximate the likelihood with great precision for the purposes of assessing ...
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Optimizing drought tolerance in cassava through genomic selection

Frontiers in Plant Science
The complexity of selecting for drought tolerance in cassava, influenced by multiple factors, demands innovative approaches to plant selection. This study aimed to identify cassava clones with tolerance to water stress by employing truncated selection ...
Weverton Gomes da Costa, Massaine Bandeira e Souza, Camila Ferreira Azevedo, Moyses Nascimento, Carolina Vianna Morgante, Jerônimo Constantino Borel, Eder Jorge de Oliveira   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Factors associated with ovine footrot lesions in Uruguayan flocks: a cross-sectional study

Frontiers in Veterinary Science
Ovine footrot has Dichelobacter nodosus as the primary pathogen, and it is characterized by its infectious and multifactorial nature, such as environmental conditions, management practices, and host susceptibility, leading to variable prevalence and ...
Waldemir Santiago Neto, Ana Crescionini, Ludmila Slimovich, Caroline da Silva Silveira, Sofía Salada, Martín Fraga, Sergio Fierro   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Calculation method for natural vibration frequency of stern cabin in oceanographic research vessel

Zhongguo Jianchuan Yanjiu, 2017
Vibration prediction for stern cabins is an important part of research into the global vibration of ships. To address the need to improve precision and efficiency, a study is carried out on the proportion of a mixed model and the length of a 3D stern ...
LIU Xi'an, WU Guangming, LI Weijie
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source