Results 71 to 80 of about 3,604,166 (239)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Joint Predictors of Hypertension and Type 2 Diabetes Among Adults Under Treatment in Amhara Region (North-Western Ethiopia)

Diabetes, Metabolic Syndrome and Obesity, 2021
Awoke Seyoum Tegegne Department of Statistics, Bahir Dar University, Bahir Dar, EthiopiaCorrespondence: Awoke Seyoum TegegneDepartment of Statistics, Bahir Dar University, Bahir Dar, EthiopiaTel +251918779451Email bisrategebrail@yahoo.comBackground: One ...
Tegegne AS
doaj  

Mixed Methods for Mixed Models

, 2014
This work bridges the frequentist and Bayesian approaches to mixed models by borrowing the best features from both camps: point estimation procedures are combined with priors to obtain accurate, fast inference while posterior simulation techniques are developed that approximate the likelihood with great precision for the purposes of assessing ...
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Optimizing drought tolerance in cassava through genomic selection

Frontiers in Plant Science
The complexity of selecting for drought tolerance in cassava, influenced by multiple factors, demands innovative approaches to plant selection. This study aimed to identify cassava clones with tolerance to water stress by employing truncated selection ...
Weverton Gomes da Costa, Massaine Bandeira e Souza, Camila Ferreira Azevedo, Moyses Nascimento, Carolina Vianna Morgante, Jerônimo Constantino Borel, Eder Jorge de Oliveira   +6 more
doaj   +1 more source

Latitude: A Model for Mixed Linear-Tropical Matrix Factorization

, 2018
Nonnegative matrix factorization (NMF) is one of the most frequently-used matrix factorization models in data analysis. A significant reason to the popularity of NMF is its interpretability and the `parts of whole' interpretation of its components ...
Hook, James, Karaev, Sanjar, Miettinen, Pauli   +2 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Factors associated with ovine footrot lesions in Uruguayan flocks: a cross-sectional study

Frontiers in Veterinary Science
Ovine footrot has Dichelobacter nodosus as the primary pathogen, and it is characterized by its infectious and multifactorial nature, such as environmental conditions, management practices, and host susceptibility, leading to variable prevalence and ...
Waldemir Santiago Neto, Ana Crescionini, Ludmila Slimovich, Caroline da Silva Silveira, Sofía Salada, Martín Fraga, Sergio Fierro   +6 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Varied Immunological Response to Test and Treat with Antiretroviral Therapy: A Longitudinal Study with Mixed Model Analysis

Indian Journal of Community Medicine
Background: The Test and Treat Policy (2017) of antiretroviral therapy (ART) was launched in India to achieve treatment goals more effectively than previous strategies.
Manvendra Singh Rathore, Mohamed Anas Mohamed Faruk Patni, Rajesh Gopal, U. C. Samudyatha, J K Kosambiya   +4 more
doaj   +1 more source