Results 131 to 140 of about 780,588 (296)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A Mixed Initiative Model for Quality-Based E-Services Pricing

, 2011
E-service pricing has become an important issue for the era of the service economy. In this study, we propose a novel pricing approach for e-services which considers perceived e-service premium.
張瑋倫; Chang, Wei-lun, Wei-Lun Chang
core   +1 more source

The effect of mixed honeybee drone semen on sperm quality characteristics: A preliminary study

African Entomology
Following copulation, sperm of multiple honeybee (Apis mellifera (A.m.) Linnaeus (Apidae)) drones are mixed inside the spermatheca of a queen, and sperm behaviour in this environment is of importance for sperm survival and successful fertilization.
Retha Kotze, Gerhard van der Horst, Janice F Murray, Anja Duminy, Mike Allsopp   +4 more
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

EFFECTIVE COLLEGE TEACHING AND STUDENTS’ RATINGS OF TEACHERS: WHAT STUDENTS THINK, WHAT FACULTY BELIEVE, AND HAT ACTUAL RATINGS SHOW IMPLICATIONS FOR POLICY AND PRACTICE IN TEACHING QUALITY ASSURANCE AND CONTROL IN HIGHER EDUCATION IN OMAN [PDF]

, 2011
This study examines the extent to which teachers’ (N=248) and students’ (N=968) perceptions of effective teaching and students’ evaluations of teachers in six colleges of technology in Oman match or mismatch. It also investigates Omani students’ (N=922)
Al-Hinai, Nasser Said, AL-HINAI, NASSER,SAID   +1 more
core  

Electrochemical Characteristics of Austenitic Stainless Steel in Mixed Chloride - Molybdate Solutions

, 2017
The effect of molybdate addition to chloride solutions on resistance of AISI 316Ti stainless steel to pitting corrosion was studied. Potentiodynamic polarization tests were performed in 1 M and 0.1 M chloride acidified solutions with various additions of
Anna Wrobel-Knysak, Lenka Markovicova, Viera Zatkalikova   +2 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Information Quality Training Requirements Analysis Guideline Demonstrated in a Healthcare Context [PDF]

, 2011
In recent years, organizations have realized the critical importance of Information Quality Management (IQM) as a means to achieve long-term business success.
Levis, Mary
core