Results 31 to 40 of about 232,906 (264)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

“I Am The New America”: Representing and Negotiating American Families in Mixed Race Memoirs

open access: yesCoSMO, 2018
This article provides an analysis of two mixed race memoirs from the 1990s/ 2000s. It looks at the establishment of mixed race families and mixed race history by these texts and contextualizes them in the larger process of the American nation coming to ...
Julia Sattler
doaj   +1 more source

Race/ethnicity differences in risk and protective factors for marijuana use among U.S. adolescents

open access: yesBMC Public Health, 2021
Background Little is known about how race and ethnicity influence marijuana-specific risk and protective factors in U.S. adolescents. We examined differences in risk and protective factors of marijuana use (MU) and their associations with MU by race ...
Meen Hye Lee   +2 more
doaj   +1 more source

Le Penant et le Dareste face au statut juridique des métis nés de parents inconnus. Une étude comparative (1891-1946)

open access: yesClio@Themis, 2021
In the end of the 19th century, the Recueil Dareste and the Recueil Penant are a part of main French periodicals specialized in colonial law. Through a complete perusal of these two reviews, this contribution aims at realizing a thematic and comparative ...
Silvia Falconieri
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Race and Mortality in Hemodialysis Patients in BrazilPlain-Language Summary

open access: yesKidney Medicine, 2022
Rationale & Objective: Studies in the United States and United Kingdom generally report better survival for Black than White patients undergoing maintenance hemodialysis, a finding not explained by differences in sociodemographics or comorbid ...
Marcelo Barreto Lopes   +9 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Multiplicity within Singularity: Racial Categorization and Recognizing “Mixed Race” in Singapore

open access: yesJournal of Current Southeast Asian Affairs, 2011
“Race” and racial categories play a significant role in everyday life and state organization in Singapore. While multiplicity and diversity are important characteristics of Singaporean society, Singapore's multiracial ideology is firmly based on separate,
Zarine L. Rocha
doaj   +2 more sources

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