Results 41 to 50 of about 232,906 (264)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
#Wasian Check: Remixing ‘Asian + White’ Multiraciality on TikTok
Genealogy, 2022 TikTok is the fastest growing short video application and immensely popular with younger generations to express their thoughts, ideas, and most relevant to this issue, their identities including mixed-race identity.
Rebecca Chiyoko King-O’Riain
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Mixed race thought: making and unmaking (mixed) race
Critique of AnthropologyAcross the globe, racial and ethnic categories continue to play a central role in the regulation and organisation of social and political life. Mixed-race in all its forms requires us to move beyond categorical thinking and question epistemological and methodological singularities.
openaire +3 more sources
Comparison of serum creatinine levels in different color/race categories in a Brazilian population
Cadernos de Saúde Pública, 2015 Serum creatinine (sCr) is usually higher among black people in the United States due to increased muscle mass, justifying the addition of race adjustment in creatinine-based formulas to estimate glomerular filtration rate (eGFR).
Roberto Carlos de Brito Barcellos +4 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The De/Construction of Identity: The Complexities of Loss and Separation for Mixed-Race Britain
GenealogyIn the 2017 Danzy Senna novel, New People, the mixed-race protagonist is described as a white ‘passing’ mixed-race woman who interprets the death of her adopted Black mother as a symbol of the death of her Black identity.
Rhianna Garrett
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Genealogy, 2022 Developments in reproductive (e.g., assisted reproduction, surrogacy) and genetic technologies (commercial DNA ancestry testing) have opened new routes to mixedness that disrupt the relationship between multiracialism and family.
Kimberly DaCosta
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source