Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Migrants employ mixed strategies to route across the Great Lakes basin
Millions of migrants encounter the Great Lakes during spring and autumn migratory movements. How migrants behave when encountering these lakes is relatively unknown at the local and basin scales.
Michael T. Wells +3 more
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Do soccer players play the mixed-strategy Nash equilibrium? [PDF]
Mixed-strategy Nash equilibrium (MSNE) is a commonly-used solution concept in game-theoretic models in various fields in economics, management, and other disciplines, but the experimental results whether the MSNE predicts well actual play in games is ...
Azar, Ofer H., Bar-Eli, Michael
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
The Implementation of Human Resources Management Strategy within Restaurants in East London, South Africa. [PDF]
Investors are generally ensuring a sufficient return on investment by crafting and implementing relevant strategies and look for excellence in what they invest in, especially when it comes to restaurants.
Zwelethu Mtshokotshe
doaj
The implementation of human resources management strategy within restaurants in East London, South Africa [PDF]
Investors are ensuring a sufficient return on investment by crafting and implementing relevant strategies. The study sought to investigate the implementation of human resources management strategy within restaurants in a sample of businesses in the ...
Mr Sibongile Ngaka +1 more
doaj
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Statistical data regarding the situation of graduates (e.g. the ease of finding a job, initial salary) indicate that the decision to study at a university can be perceived as fully rational.
Paweł Ziemiański, Krzysztof Zięba
doaj +1 more source

