Results 51 to 60 of about 5,986,962 (301)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Research on MPPT Algorithm Based on Mixed Strategy

open access: yesMATEC Web of Conferences, 2017
Based on the mathematical model of PV array and its output characteristics, a hybrid control strategy combining fixed step method and variable coefficient approximation method is proposed.
Chai Yu, Fang Xu
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Growth strategy of microbes on mixed carbon sources

open access: yesNature Communications, 2019
Bacteria grown on two carbon sources either consume both sources simultaneously or consume them sequentially. Here the authors use a metabolic network model of E.
Xin Wang   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Connecticut's transportation strategy

open access: yes, 2011
Title from PDF cover (publisher's Web site, viewed Mar. 23, 2011).; "Section 13b-57g, General Statutes of Connecticut"--P. 3.; "January, 2011."; Updates: Moving forward.

core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

National E-Waste Management Strategy 2019-2024 [PDF]

open access: yes, 2019
The National E-waste Management Strategy is a five-year plan covering the period 2019/20 to 2023/24. The E-waste Strategy has five thematic areas aimed at resource mobilization for proper E-waste management, raising awareness, strengthening Kenya’s E ...

core  

A new method to optimize the reliability of repairable components with a switching mechanism and considering costs and weight uncertainty [PDF]

open access: yesInternational Journal of Industrial Engineering and Production Research
The reliability of each component in a system plays a crucial role, as any malfunction can significantly reduce the system's overall lifespan. Optimizing the arrangement and sequence of heterogeneous components with varying lifespans is essential for ...
pardis roozkhosh   +1 more
doaj  

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