Results 61 to 70 of about 9,830,689 (286)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Robust mixed H-2/H∞ control for a class of nonlinear stochastic systems [PDF]

, 2006
The problem of mixed H2/H∞ control is considered for a class of uncertain discrete-time nonlinear stochastic systems. The nonlinearities are described by statistical means of the stochastic variables and the uncertainties are represented by deterministic
Wang, Z, Ho, DWC, Yang, F
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

General Solution and Stability of Additive-Quadratic Functional Equation in IRN-Space

Journal of Function Spaces, 2021
The investigation of the stabilities of various types of equations is an interesting and evolving research area in the field of mathematical analysis. Recently, there are many research papers published on this topic, especially additive, quadratic, cubic,
K. Tamilvanan, Nazek Alessa, K. Loganathan, G. Balasubramanian, Ngawang Namgyel   +4 more
doaj   +1 more source

Nonlinear Integrodifferential Equations of Mixed Type in Banach Spaces

International Journal of Mathematics and Mathematical Sciences, 2007
We prove two existence theorems for the integrodifferential equation of mixed type:x'(t)=f(t,x(t),∫0tk1(t,s)g(s,x(s))ds,∫0ak2(t,s)h(s,x(s))ds),x(0)=x0, where in the first part of this paperf, g, h, xare functions with values in a Banach spaceEand integrals are taken in the sense of Henstock-Kurzweil (HK).
Aneta Sikorska-Nowak, Nowak Grzegorz Krzysztof   +1 more
openaire   +4 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

On the Rodrigues Formula Solution of the Hypergeometric-Type Differential Equation [PDF]

, 2013
In this paper, we present a new systematic approach to the solution of the hypergeometric-like differential equation and its associated equation. The method produces, tout court, the general solution of these equations in the form of a combination of a ...
Robin, William
core   +1 more source

Existence and uniqueness for some equation of a mixed elliptic-hyperbolic type

Boundary Value Problems, 2019
In the paper, we prove results on existence and uniqueness of weak solutions for closed Dirichlet problem for a transonic flow model, and interior regularity results are also given in the important special case of the Tricomi equation.
Zhang Haixia, Xiao Wei
doaj   +1 more source