Results 111 to 120 of about 301,664 (295)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Varactor high level mixer [PDF]

, 1969
Varactor microwave frequency mixing ...
Penque, N. J., Rosen, H. A.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Enhancement of Spurious Signal Suppression in Microstrip Mixers by Load Resistor Termination

Sensors
The mixer is an essential component in RF transceiver subsystems. It has a role in shifting the signal frequency for more convenient processing of up-conversion as well as down-conversion.
Catur Apriono, Abdurrasyid Ruhiyat, Farohaji Kurniawan, Arokiaswami Alphones, Fitri Yuli Zulkifli   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Comparison of measured and predicted performance of a SIS waveguide mixer at 345 GHz [PDF]

The measured gain and noise of a SIS waveguide mixer at 345 GHz have been compared with theoretical values, calculated from the quantum mixer theory using a three port model.
Degraauw, T., Delange, G., Dierichs, M. M. T. M., Honingh, C. E., Klapwijk, T. M., Schaeffer, H. H. A., Vandekuur, J., Wezelman, J.   +7 more
core   +1 more source

New 60-cm Radio Survey Telescope with the Sideband-Separating SIS Receiver for the 200 GHz Band

, 2007
We have upgraded the 60-cm radio survey telescope located in Nobeyama, Japan. We developed a new waveguide-type sideband-separating SIS mixer for the telescope, which enables the simultaneous detection of distinct molecular emission lines both in the ...
Asayama, Shin'ichiro, Dobashi, Kazuhito, Handa, Toshihiro, Kaiden, Masahiro, Kimura, Kimihiro, Kohno, Kotaro, Korogi, Jun, Morino, Jun-Ichi, Nakajima, Taku, Nishiura, Shingo, Noguchi, Takashi, Ogawa, Hideo, Yonekura, Yoshinori   +12 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Mathematical models for water treatment problems

Nauka ta progres transportu
Purpose. Assessing the efficiency of water treatment in different structures is a problem of big importance. To solve this a problem, it is necessary to have mathematical models that allow to quickly obtain data on the cleaning effect in different ...
M. M. Biliaiev, V. A. Kozachyna, M. V. Kyrychenko, M. O. Skuratov, A. O. Chirkov, H. K. Filonenko   +5 more
doaj   +1 more source