Results 121 to 130 of about 2,640,579 (332)

Irreversible nitrate fluxes due to turbulent mixing in a coastal upwelling system [PDF]

, 2005
Burke Hales, James N. Moum, Paul A. Covert, A. Perlin   +3 more
openalex   +1 more source

Neutrino mass, mixing and discrete symmetries

, 2013
Status of the discrete symmetry approach to explanation of the lepton masses and mixing is summarized in view of recent experimental results, in particular, establishing relatively large 1-3 mixing.
Smirnov, Alexei Y.
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Mixed Cages

Graphs and Combinatorics, 2019
We introduce the notion of a $[z, r; g]$-mixed cage. A $[z, r; g]$-mixed cage is a mixed graph $G$, $z$-regular by arcs, $r$-regular by edges, with girth $g$ and minimum order. In this paper we prove the existence of $[z, r ;g]$-mixed cages and exhibit families of mixed cages for some specific values.
Araujo-Pardo, Gabriela, Hernández-Cruz, César, Montellano-Ballesteros, Juan José   +2 more
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

No Emergence of Deep Convection in the Arctic Ocean Across CMIP6 Models

Geophysical Research Letters
As sea ice disappears, the emergence of open ocean deep convection in the Arctic, which would enhance ice loss, has been suggested. Here, using 36 state‐of‐the‐art climate models and up to 50 ensemble members per model, we show that Arctic deep ...
Céline Heuzé, Hailong Liu
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

DOUBLE-DIFFUSIVE MIXING IN STELLAR INTERIORS IN THE PRESENCE OF HORIZONTAL GRADIENTS [PDF]

, 2014
M. Medrano, P. Garaud, S. Stellmach
openalex   +1 more source