Results 121 to 130 of about 3,605,477 (339)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Provision Point-Source Materials Stimulates Play in Sows but Does Not Affect Aggression at Regrouping

Animals, 2018
When sows are mixed into groups, hierarchies form and resulting aggression and stress can affect production and welfare. This study determined the effect of providing point-source materials on aggressive and play behaviors in gestating sows.
Emma Catharine Greenwood, William H. E. J. van Wettere, Jessica Rayner, Paul E. Hughes, Kate L. Plush   +4 more
doaj   +1 more source

Mixed Cages

Graphs and Combinatorics, 2019
We introduce the notion of a $[z, r; g]$-mixed cage. A $[z, r; g]$-mixed cage is a mixed graph $G$, $z$-regular by arcs, $r$-regular by edges, with girth $g$ and minimum order. In this paper we prove the existence of $[z, r ;g]$-mixed cages and exhibit families of mixed cages for some specific values.
Araujo-Pardo, Gabriela, Hernández-Cruz, César, Montellano-Ballesteros, Juan José   +2 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Biocompatibility of a droplet-mixing device using an electro-conjugate fluid

Mechanical Engineering Journal, 2016
An electro-conjugate fluid (ECF) is a type of functional fluid that produces a jet flow under a non-uniform electric field. We use an ECF to generate a rotational flow in a tiny cylindrical chamber.
Kenjiro TAKEMURA, Kiho KOBAYASHI, Kazuya EDAMURA   +2 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

No Emergence of Deep Convection in the Arctic Ocean Across CMIP6 Models

Geophysical Research Letters
As sea ice disappears, the emergence of open ocean deep convection in the Arctic, which would enhance ice loss, has been suggested. Here, using 36 state‐of‐the‐art climate models and up to 50 ensemble members per model, we show that Arctic deep ...
Céline Heuzé, Hailong Liu
doaj   +1 more source