Results 121 to 130 of about 865,428 (296)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
A developed stage of Alfven wave phase mixing [PDF]
, 2000 Alfven wave phase mixing is an extensively studied mechanism for dissipating wave energy in an inhomogeneous medium. It is common in the vast majority of phase mixing papers to assume that even though short scale lengths and steep gradients develop as a ...
Arber, Tony +3 more
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Chaotic mixing and mixing efficiency in a short time [PDF]
Fluid Dynamics Research, 2008 Several studies of the chaotic motion of fluid particles by two-dimensional time-periodic flows or three-dimensional steady flows, called Lagrangian chaos, are first introduced. Secondly, some of the studies on efficient mixing caused by Lagrangian chaos, called chaotic mixing, are reviewed with discussion of several indices for the estimation of ...
openaire +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The Effect of Turbulence Modeling on the Mixing Characteristics of Several Fuel Injectors at Hypervelocity Flow Conditions [PDF]
CFD analysis is presented on the effects of turbulence modeling choices on the mixing characteristics and performance of three fuel injectors at hypervelocity flow conditions.
Baurle, Robert A. +4 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Supersonic combustor modeling [PDF]
The physical phenomena involved when a supersonic flow undergoes chemical reaction are discussed. Detailed physical models of convective and diffusive mixing, and finite rate chemical reaction in supersonic flow are presented.
Carpenter, Mark H. +2 more
core +1 more source
Improving the design and operation of a tweedy dough mixer [PDF]
, 1997 Compared with other cereals, wheat is special because the dough that it makes, when mixed with water and other ingredients, has the following unique properties: 1. It forms a viscoelastic material. 2.
Anderssen, R.S., Stump, D.
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