Results 81 to 90 of about 699,277 (302)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
EnergiesThe presented study focuses on evaluating the mixing properties of structures derived from the so-called sheet-gyroid geometry and their modifications as advanced mixing elements in renewable energy technologies.
Martin Beer, Radim Rybár
doaj +1 more source
Novel Fiber Design for Wideband Conversion and Amplification in Multimode Fibers
, 2017 We propose an operating principle to achieve broadband and highly tunable mode conversion and amplification exploiting inter-modal four wave mixing in a multimode fiber.
Guasoni, M. +3 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
On indecomposable trees in the boundary of Outer space
, 2010 Let $T$ be an $\mathbb{R}$-tree, equipped with a very small action of the rank $n$ free group $F_n$, and let $H \leq F_n$ be finitely generated. We consider the case where the action $F_n \curvearrowright T$ is indecomposable--this is a strong mixing ...
Reynolds, Patrick
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Predicting mixed-meal measured glycaemic index in healthy subjects
European Journal of Nutrition, 2018 To determine the influence of meal composition on the glycaemic impact of different carbohydrate staples, and the accuracy of "adjusted calculated meal GI" compared with "measured mixed-meal GI".In a non-blind randomized crossover trial fasted healthy subjects consumed four dinner-type mixed meals of realistic serving size comprising a carbohydrate ...
Ballance, Simon +4 more
openaire +3 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Superstatistics Based on the Microcanonical Ensemble
, 2005 Superstatistics is a "statistics" of "canonical-ensemble statistics". In analogy, we consider here a similar theoretical construct, but based upon the microcanonical ensemble.
Plastino, A. +2 more
core +2 more sources