Results 91 to 100 of about 2,433,116 (369)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Neutrino mass and mixing with discrete symmetry [PDF]

Reports on progress in physics. Physical Society, 2013
This is a review paper about neutrino mass and mixing and flavour model building strategies based on discrete family symmetry. After a pedagogical introduction and overview of the whole of neutrino physics, we focus on the PMNS mixing matrix and the ...
S. King, C. Luhn
semanticscholar   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Quark Mass Hierarchies, Flavor Mixing and Maximal CP-Violation [PDF]

, 1998
Flavor mixing and the quark mass spectrum are intimately related. In view of the observed strong hierarchy of the quark and lepton masses and of the flavor mixing angles it is argued that the description of flavor mixing must take this into account.
C. Jarlskog, H. Fritzsch, H. Fritzsch, H. Fritzsch, H. Fritzsch, H. Fritzsch, H. Fritzsch, H. Fritzsch, H. Fritzsch, H. Fritzsch, H. Fritzsch, H. Harari, H. Lehmann, K.S. Babu, L. Maiani, L. Wolfenstein, L.J. Hall, L.L. Chau, M. Kobayashi, M. Neubert, N. Cabibbo, R. Barbieri, R.M. Barnett, S. Dimopoulos   +23 more
core   +2 more sources

Renormalization of mixing angles [PDF]

Journal of High Energy Physics, 2018
A bstractWe discuss the renormalization of mixing angles for theories with extended scalar sectors. Motivated by shortcomings of existing schemes for mixing angles, we review existing renormalization schemes and introduce new ones based on on-shell ...
A. Denner, S. Dittmaier, J. Lang
semanticscholar   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

CP Violation in $D^0-\overline{D^0}$Mixing

, 1995
The existence of $D^0-\overline{D^0}$ mixing at a detectable level requires new physics, which effectively yields a $\Delta c = 2$ superweak interaction. In general this interaction may involve significant CP violation.
H. Georgi, I. I. Bigi, J. Donoghue, L. Wolfenstein, L. Wolfenstein, Lincoln Wolfenstein, Y. Grossman, Y. L. Wu, Y. Nir   +8 more
core   +1 more source

Turbulent mixing and transition criteria of flows induced by hydrodynamic instabilities

Physics of Plasmas, 2018
In diverse areas of science and technology, including inertial confinement fusion (ICF), astrophysics, geophysics, and engineering processes, turbulent mixing induced by hydrodynamic instabilities is of scientific interest as well as practical ...
Ye Zhou, T. Clark, D. Clark, S. Gail Glendinning, M. Aaron Skinner, C. Huntington, O. Hurricane, A. Dimits, B. Remington   +8 more
semanticscholar   +1 more source

Nonlinear one-way edge-mode interactions for frequency mixing in topological photonic crystals [PDF]

Physical review B, 2019
Topological photonics aims to utilize topological photonic bands and corresponding edge modes to implement robust light manipulation, which can be readily achieved in the linear regime of light-matter interaction. Importantly, unlike solid-state physics,
Z. Lan, J. You, N. Panoiu
semanticscholar   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source