Results 61 to 70 of about 2,680,157 (305)
Journal of Mathematical Physics, 2002 An index evaluating the amount of chirality of a mixture of colored random variables is defined. Properties are established. Extreme chiral mixtures are characterized and examples are given. Connections between chirality, Wasserstein distances, and least squares Procrustes methods are pointed out.
openaire +3 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Poincaré and Log–Sobolev Inequalities for Mixtures
Entropy, 2019 This work studies mixtures of probability measures on R n and gives bounds on the Poincaré and the log–Sobolev constants of two-component mixtures provided that each component satisfies the functional inequality, and both components are close in ...
André Schlichting
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Sampling from Dirichlet process mixture models with unknown concentration parameter: mixing issues in large data implementations [PDF]
, 2014 We consider the question of Markov chain Monte Carlo sampling from a general stick-breaking Dirichlet process mixture model, with concentration parameter (Formula presented.).
Silvia Liverani +5 more
core +1 more source
Entropic Behavior of Binary Carbonaceous Mesophases
Entropy, 2008 The Maier-Saupe model for binary mixtures of uniaxial discotic nematogens, formulated in a previous study [1], is used to compute and characterize orientational entropy [2] and orientational specific heat.
Alejandro D. Rey, Mojdeh Golmohammadi
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Exploration of Computational Approaches to Predict the Toxicity of Chemical Mixtures
Toxics, 2019 Industrial advances have led to generation of multi-component chemicals, materials and pharmaceuticals which are directly or indirectly affecting the environment.
Supratik Kar, Jerzy Leszczynski
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source