Results 251 to 260 of about 2,955,171 (326)

Multiscale homogenized constrained mixture model of the bio-chemo-mechanics of soft tissue growth and remodeling. [PDF]

Biomech Model Mechanobiol
Paukner D, Humphrey JD, Cyron CJ.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Bayesian mixture model for accurate assessment of monthly maximum wind speed: A case study in Gwadar. [PDF]

Heliyon
Khan T, Wang Y.
europepmc   +1 more source

On flexible random field models for spatial statistics: Spatial mixture models and deformed SPDE models

, 2019
Anders Hildeman
openalex   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Negative binomial mixture model for identification of noise in antibody-antigen specificity predictions from single-cell data. [PDF]

Bioinform Adv
Wasdin PT, Abu-Shmais AA, Irvin MW, Vukovich MJ, Georgiev IS.   +4 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Adaptive Model Predictive Control for 4WD-4WS Mobile Robot: A Multivariate Gaussian Mixture Model-Ant Colony Optimization for Robust Trajectory Tracking and Obstacle Avoidance. [PDF]

Sensors (Basel)
Ait Dahmad H, Ayad H, García Cerezo A, Mousannif H.   +3 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

The Association between Autistic Traits and Trajectories of Anxiety in Middle-Aged and Older Adults: An 8-year Growth Mixture Model Analysis

Stewart G, Eshetu A, Ghai S, Corbett A, Ballard C, Hampshire A, O'Nions E, Mandy W, Stott J, John A, Stewart G.   +10 more
europepmc   +1 more source