Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
A national growth mixture modeling analysis of county-level COVID-19 incidence rate trajectories and health inequities during three successive pandemic waves in 2020. [PDF]
Sci RepDukes K +15 more
europepmc +1 more source
Identifying prospective subpopulations of combustible and electronic cigarette dual users in the United States via finite mixture modeling. [PDF]
Addiction, 2022 Sutton SK +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Longitudinal patterns of mental well-being over four years in a german general population sample: a growth mixture modeling approach. [PDF]
BMC Public HealthFischer J +4 more
europepmc +1 more source
A Novel Multi-Region, Multi-Phase, Multi-Component-Mixture Modeling Approach to Predicting the Thermodynamic Behaviour of Thermoplastic Composites during the Consolidation Process. [PDF]
Polymers (Basel), 2022 Kobler E +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Latent class growth mixture modeling of HbA1C trajectories identifies individuals at high risk of developing complications of type 2 diabetes mellitus in the UK Biobank. [PDF]
BMJ Open Diabetes Res CareHandley D +4 more
europepmc +1 more source
Growth Mixture Modeling With Nonnormal Distributions: Implications for Data Transformation. [PDF]
Educ Psychol Meas, 2021 Nam Y, Hong S.
europepmc +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source